ID A0A1S3W7Y5_ERIEU Unreviewed; 436 AA.
AC A0A1S3W7Y5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=GTPase Era, mitochondrial {ECO:0000256|ARBA:ARBA00019149};
DE AltName: Full=ERA-like protein 1 {ECO:0000256|ARBA:ARBA00030975};
GN Name=ERAL1 {ECO:0000313|RefSeq:XP_016042470.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042470.1};
RN [1] {ECO:0000313|RefSeq:XP_016042470.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable GTPase that plays a role in the mitochondrial
CC ribosomal small subunit assembly. Specifically binds the 12S
CC mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating
CC the 3' terminal stem-loop region. May act as a chaperone that protects
CC the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small
CC subunit assembly. {ECO:0000256|ARBA:ARBA00025227}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Era GTPase family. {ECO:0000256|ARBA:ARBA00007921,
CC ECO:0000256|PROSITE-ProRule:PRU01050}.
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DR RefSeq; XP_016042470.1; XM_016186984.1.
DR AlphaFoldDB; A0A1S3W7Y5; -.
DR GeneID; 103111189; -.
DR CTD; 26284; -.
DR OrthoDB; 5490026at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd04163; Era; 1.
DR CDD; cd22534; KH-II_Era; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030388; G_ERA_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR005662; GTPase_Era.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42698; GTPASE ERA; 1.
DR PANTHER; PTHR42698:SF1; GTPASE ERA, MITOCHONDRIAL; 1.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 1.
DR PROSITE; PS51713; G_ERA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PROSITE-
KW ProRule:PRU01050}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU01050}; Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 112..329
FT /note="Era-type G"
FT /evidence="ECO:0000259|PROSITE:PS51713"
FT REGION 120..127
FT /note="G1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 146..150
FT /note="G2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 166..169
FT /note="G3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 235..238
FT /note="G4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT REGION 307..309
FT /note="G5"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
SQ SEQUENCE 436 AA; 48865 MW; 94C9FEF4E6CFD976 CRC64;
MAAPSRCSAV LFRTVLRFWR LGQDAGRERV ALRPLLLGSQ WRCLSCVVGT ALSGPRLAPA
SRRYGQGSAL DRFLGLSRPD SSLPSRVPAV PLNRDDQDLL LVHSPDMPEN PRVLRVVLLG
APNAGKSTLS NQLLGRKVFP VSKKVHTTRC QALGVFTENE AQILLDTPGL ISPTKQKRHH
LESSLLEDPW KSMESADLVV VLVDVSDKWT RNQLSPQLLQ CLTKFSQVPS ILVMNKVDCL
KQKSVLLDLS VVLTEGIVNG KKFEMGQDLR SYQDTYYLSR VSKSPDPESV GKPQRTGWPH
FQEIFMLSSL SQEDVHILKQ YLLSKAQPGP WEFHSEVLTS QMPEEICANI IREKLLEHLP
QEVPYSVQQQ TVVWEKGPSG ELLILQKLLV SKESHMKLLI GLKGHMIAQI AEEVGRDLMN
IFLCDVQLRL SVKLLK
//