ID A0A1S3W874_ERIEU Unreviewed; 808 AA.
AC A0A1S3W874;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Structural maintenance of chromosomes protein 6 {ECO:0000313|RefSeq:XP_016042560.1};
GN Name=SMC6 {ECO:0000313|RefSeq:XP_016042560.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042560.1};
RN [1] {ECO:0000313|RefSeq:XP_016042560.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
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DR RefSeq; XP_016042560.1; XM_016187074.1.
DR AlphaFoldDB; A0A1S3W874; -.
DR STRING; 9365.ENSEEUP00000013313; -.
DR CTD; 79677; -.
DR eggNOG; KOG0250; Eukaryota.
DR InParanoid; A0A1S3W874; -.
DR OrthoDB; 78166at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 52..259
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 232..259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 285..340
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 662..696
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..794
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 808 AA; 92942 MW; 9E803EE38CFA13C8 CRC64;
MAKRKEDDFF SPENAKRPRL EELEDLDDDE CAVSFTNGTS ALTAAEVGII ESIQLKNFMC
HSMLGPFKFG SNVNFVVGNN GSGKSAVLTA LIVGLGGKAI ATNRGSSLKG FVKDGQNSAD
ISITLRNRGD DAYRANVYGD SIVVQQHISM DGSRSYKLKS ESGSVVSTKK EELVAILDHF
NIQVDNPVSV LTQEMSKQFL QSKNEGDKYK FFMKATQLEQ MKEDYSYIME TKERTKEQIS
QGEERLTELK RQCLEKEERF QSIAGLSTMK TNLEYLKHEM AWAVVNEIEK QLNAIRDNIK
IGEDRAARLE RKTEEQQVRL NEAEKKYKDI QDKLEHISQE TNAQAPECMA LKLDLANKKK
AYNEAEVVYN RSLNEYRALR KDDEQLCKRI EELKSTDQSL EPERLERQKK IAWLKEKVKT
LQDQDSTSLQ DIEQFQQAIE KDKEEHSRIM REELDVKHTL SYNQRQLKEL KDSKTDRLKR
FGPHVPALLA AIDDAYRRKQ FAYKPVGPLG ACIHLRDPEL ALAIESCLKG LLQAYWCHSH
ADERVLQGLM KKFYSPGTSR PQIIVSEFRK EMYDVRQRAA YHPEFPTVLT ALEIDNAVVA
NSLIDMRGIE TVLLIKNNSV ARAVMQSQRP PRNCREAFTA DGDQVFAGRY YSSENTRPKF
LSRDVDSEIS ELENEIENKK AQILNLQQHL STLEKDIGRN EDFLRKCQLH SKELKMKIRK
NCSEIRELEN IEEHQSVDIA TLEDEAHENK IKMKMVEKNM EQQRENMEHL RSLKIEAEKK
YDAIKLKINQ LSEQADPLKV KMSFFPAT
//
