ID A0A1S3W875_ERIEU Unreviewed; 1316 AA.
AC A0A1S3W875;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 1-like {ECO:0000313|RefSeq:XP_016042688.1};
GN Name=LOC103113577 {ECO:0000313|RefSeq:XP_016042688.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042688.1};
RN [1] {ECO:0000313|RefSeq:XP_016042688.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_016042688.1; XM_016187202.1.
DR CTD; 22861; -.
DR eggNOG; ENOG502S4A4; Eukaryota.
DR InParanoid; A0A1S3W875; -.
DR OrthoDB; 338452at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 238..547
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 919..1202
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1219..1302
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 850..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1316 AA; 149933 MW; 5149F27E1BEC341E CRC64;
MASKVQLKLA FYLSIMEKEE LKEFLLQLPE KEISGHPPME TTVQPEKADA MEVASRLVSQ
YGEQRAWELT LHTWEMMGLR RLSAQVQKEA NFMSEDSAHV YQALPNSSDH ELPSQDSPNA
PISTAVLGAW APTCKPSPVS IKQKAPATWL RDEISGSLCA EIQEEYKRGE RSCPTQSWKN
ENLLQKFTQL LLLHVSHPQH HEGFISGSWH HRKREELGFF IEIGELFGPS LDTQKEFHTI
ILHGHAGIGM STLARQVKQS WEEDQLYSDR FQHVLYFNCR ELNRFKTMSL SELISKDSAA
PDILTEQMLS QSGQMLFILD GLDELKCIMD DEGSHLSVHW RQQQPVHKLL RSLLEKIILS
EASLLITIQT SSLQKLIPSL KQPHLVEVLG FSETRRKDYF YQYFTEENQA RRALSVVESN
PALWALCLMP WVSWLACTCL KQQMRRGQEL SLTCQTTTAL CLQFLSRNLS DKSFRDQLRG
LCSLATHSIW SGETEFTPLE LMQYRLDDPV ISSLLKMGIL QKHPTSLLYN FTHLCFQEFF
AAMSCALKYT ETSDIVNPFN HVKFLLERDW RDDVFGAPTT HFLFGLLSEH GMRELESIFR
CRLSRKSKWK LSQCIQKKFQ EEQYSQQPYS LQLFHCLYEI QEQDFLIEVM THYQGTRMYL
QTDFELLIFT FCIKLCHRVK RLQLNEGGQH RQGWTPPDVV LFTCFLLTDA CWKVLFSTSG
IIGSLEELDL SGNFLSESAV QSLCEALGSS LCHLQTLSHI NLPYRLENCG LTSSCCQDLA
SALSSSPSLT ELDLCQNDLG DLGVKLLCEV LRHPSCQLRL LRLDQAQLSE EVMEMLRALQ
KEKTQLNISD SWNPHMTVPT EGPGRRDKAC DNASSFKQER PVSEGSSPQV AQVELVCLSS
SPTPVGDLHV MPVGNEDDFW GPTGPVATKL VDKEKSLYRV HFPDAGSYHW PSTGLHFVLR
RPVTIEIEFC DWKQFLDRIV PQQSWMVAGP LFDIRTDPGA VEAVYLPHFV SQQGEPVDIS
QFHVAHFKEE GMVLEQPARV EPCYTVLENP SFSPIGVLLK ILSVALSFIP INSIVLLYHH
IHLEEITFHL YLIPSDCSIR KAIDDEEKKF QFVRLHKPPP LTPLYMGSRY TVSGSQKMEI
IPQELELCYR SCGEAQLFSE IYVGHSESGI RLHITNKKDS TVVWEALVKP GDLTPAGTEA
SPSHLHTHTP PPGAPALLHF VDQCQEQLVA RVTSVDPVLD KLLGSVIDDE QYETVRAEAT
KPSQMRRLFR FSRSWDWACK DLLYQALKET HPHLIKDLWE KGRGGGELKA LDRLGS
//
