ID A0A1S3W8Q3_ERIEU Unreviewed; 623 AA.
AC A0A1S3W8Q3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Autophagy-related protein 16-1 isoform X1 {ECO:0000313|RefSeq:XP_016042384.1};
GN Name=ATG16L1 {ECO:0000313|RefSeq:XP_016042384.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042384.1};
RN [1] {ECO:0000313|RefSeq:XP_016042384.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR RefSeq; XP_016042384.1; XM_016186898.1.
DR AlphaFoldDB; A0A1S3W8Q3; -.
DR GeneID; 103110439; -.
DR CTD; 55054; -.
DR InParanoid; A0A1S3W8Q3; -.
DR OrthoDB; 458014at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF6; AUTOPHAGY-RELATED PROTEIN 16-1; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 16..206
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 334..367
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 378..419
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 420..461
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 478..500
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 556..587
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 294..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 82..230
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 301..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70093 MW; 7A3AB9283C49301D CRC64;
MSSGLRAADF PRWKRHISEE LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLVHKLQTEK
HDIPNKHEIS AGHDGAWNDS QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQQK
DREMQMNEAK IAECLQTISD LEAECLELRS KLQDLERANQ TLKDEYDALQ ITFTALEEKL
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQEDDI
EVIVDETSDH TDETSPVRTV SRVTSKRLSQ PAGGLLDSIT NIFGLSESPL LGHHSSDTAR
RRSVSSLPVP QDNVDTHPGS SKEVRVPTTA MYVFDAHDGE VNAVQFSPGS RLLATGGMDR
RVKLWEVCGE KCELKGSLSG SNAGITSIEF DSAGSYLLAA SNDFASRIWT VDDYRLRHTL
TGHSGKVLSA KFLLDNARIV SGSHDRTLKL WDLRSKVCIK TVFAGSSCND IVCTEQCVMS
GHFDKKIRFW DIRSESIVRE MELLGKITAL DLNPERTELL SCSRDDLLKI IDLRLSAVRQ
TFSAPGFKCG SDWTRVTFSP DGSYVAAGSA EGSLYVWNVL SGKVEKVLSK YHCSSINAVA
WSPSGSNVVT VDKGSKAVLW SDY
//
