ID A0A1S3WAM8_ERIEU Unreviewed; 2026 AA.
AC A0A1S3WAM8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Dedicator of cytokinesis protein 7 isoform X1 {ECO:0000313|RefSeq:XP_016043377.1};
GN Name=DOCK7 {ECO:0000313|RefSeq:XP_016043377.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016043377.1};
RN [1] {ECO:0000313|RefSeq:XP_016043377.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_016043377.1; XM_016187891.1.
DR CTD; 85440; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11703; DHR2_DOCK7; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 453..619
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1561..2000
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 29..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2026 AA; 229879 MW; 66055BC0E127FE25 CRC64;
MDPHVRDCIR SYTEDWAIVI RKYHKLGTGF NPNTLDKQKE RQKGLPKQVF ESDEAPDGNS
YQDDQDELKR RSMSIDDTPR GSWACSIFDL KNSLPDALLP NLLDRTPNEE IDHQNDDQRK
SNRHKELFAL HPSLDEEEPI ERLSVPDAPK EHFGQRLLVK CLSLKFEIEI EPIFASLALY
DAKEKKKISE NFYFDLNSEQ MKGLLRPHVP PAAITTLARS AIFSITYPSQ DVFLVIKLEK
VLQQGDIGEC AEPYMIFKEA DATKNKEKLE KLKSQADQFC QRLGKYRMPF AWTAIHLMNI
VSSAGSLERD STEVEISTGE RKGSWSERRN SSIVGRRSLE RTTSGDDACN LTSFRPATLT
VTNFFKQEGD RLSDEDLYKF LADMRRPSSV LRRLRPITAQ LKIDISPAPD NPHYCLTPEL
LQVKLYPDSR VRPTREILEF PARDVYVPNT TYRNLLYIYP QSLNLANRQG SARNITVKVQ
FMYGEDPSNA MPVIFGKSSC SEFSKEAYTA VVYHNRSPDF HEEIKVKLPA ALTDHHHLLF
TFYHVSCQQK QNTPLETPVG YTWIPMLQNG RLKTGQFCLP VSLEKPPQAY SVLSPEVPLP
GMKWVDNHKG VFNVEVVAVS SIHTQDPYLD KFFALVNALD EHMFPVRIGD MRIMENNLEN
ELKSSISALN SSQLEPVVRF LHLLLDKLIL LVVRPPVIAG QIVNLGQASF EAMASIINRL
HKNLEANHDQ HGRNSLLASY IHYVFRLPNT YPNSPSPGPG GLGGSVHYAT MARSAVRPAS
LNLNRSRSLS NSNPDISGTP TSPDDEVRSI IGNKGLDRSN SWVNTGGPKA APWGSNPSPS
ADSTQAVDRS CNRMSSHTET SSFLQTLTGR LPTKKLFHEE LALQWVVCSG SVRESALQQA
WFFFELMVKS MVHHLYFNDK LDAPRKSRFP ERFMDDISAL VSTIASDIIS RFQKDTEMVE
KLNTSLAFFL NDLLSVMDRG FVFSLIKTYY KQVSSKLYSL PNPSVLLSLR LDFLRIICSH
EHYVTLNLPC SLLTPPASPS PSVSSATSQS SGFSTNVQDQ KIANMFELSV PFRQQHYLAG
LVLTELAVIL DPDAEGLFGL HKKVINMVHN LLSSHDSDPR YSDPQIKARV AMLYLPLIGI
IMEAVPQLYD FTETHNQRGR PVCIATDDYE GESGSMISQT VAMAIAGTSV PPLTRPGSFL
LTSTSGRQHT TFSGESSRSL LICLLWVLKN ADETVLQKWF TDLSVLQLNR LLDLLYLCVS
CFEYKGKKVF ERMNSLTFKK SKDMRAKLEE AILGSIGARQ EMVRRSRGQL ERSPSGSAFG
SQENLRWRKD LTHWRQNTEK FDKSRAEIEH EALIDGNLAT EANLIILDTL EIIVQTVSVT
ESKESILGGV LKVLLHSMAC NQSAIYLQHC FATQRALVSK FPELLFEEET EQCADLCLRL
LRHCSSSIGS IRSHASASLY LLMRQNFEIG NNFARVKMQV TMSLSSLVGT SQNFNEEFLR
RSLKTILTYA EEDLELRETT FPDQVQDLVF NLHMILSDTV KMKEHQEDPE MLIDLMYRIA
KGYQTSPDLR LTWLQNMAGK HSERSNHAEA AQCLVHSAAL VAEYLSMLED RKYLPVGCVT
FQNISSNVLE ESAVSDDVLS PDEEGICSGK YFTESGLVGL LEQAAASFSM AGMYEAVNEV
YKVLIPIHEA NRDAKKLSTI HGKLQEAFSK IVHQSTGWED GKRMFGTYFR VGFYGTKFGD
LDEQEFVYKE PAITKLAEIS HRLEGFYGER FGEHVVEVIK DSNPVDKCKL DPNKAYIQIT
YGEPYFDTYE MKDRITYFDK NYNLRRFMYC TPFTLDGRAH GELHEQFKRK TILTTSHAFP
YIKTRVNVTH KEEIILTPIE VAIEDMQKKT QELAFATHQD PADPKMLQMV LQGSVGTTVN
QGPLEVAQVF LSEIPSDPKL FRHHNKLRLC FKDFTKRCED ALRKNKSLIG PDQKEYQREL
ERNYHRLKEA LQPLINRKIP QLYKAALPTT CHRDSFSRMS LRKMDL
//
