ID A0A1S3WAR3_ERIEU Unreviewed; 1483 AA.
AC A0A1S3WAR3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 2 isoform X3 {ECO:0000313|RefSeq:XP_016043159.1};
GN Name=CAMSAP2 {ECO:0000313|RefSeq:XP_016043159.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016043159.1};
RN [1] {ECO:0000313|RefSeq:XP_016043159.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR RefSeq; XP_016043159.1; XM_016187673.1.
DR GeneID; 103112653; -.
DR CTD; 23271; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF1; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 211..324
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1345..1479
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 436..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 748..775
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 875..912
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 442..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1483 AA; 167358 MW; 277363A00355ABBF CRC64;
MGDAADPREM RKTFIVPAIK PFDHYDFPRA KIACNLAWLV AKAFGTDNVP EELREPFYTD
QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH DAVIQALAQK GLYVTDQEKL
VTERDLHKKP IQMSAHLAMI DTLMMAYTVE MVSVEKVITC AQQYSTFFQA TDLPYDIEDA
VMYWINKVNE HLKDIMEQEQ KLKEHHTIEA PGGQKARYRK EQTLLKQLPC IPLVENLLKD
GADGCAVAAL IHFYCPGVVR LEDICLKETM SLADSLYNLQ LIQEFCQEYL NQCCHFTLED
MLYAASSIKS NYLVFMAELF WWFEVVKPSF VQPRVVCPQG AEPMKDMPVL NTAKRNTLDS
SYSSDFSPCG EGATFAHSHH LSSRYSRPQA HSSASGGIRR SSSMSYVDGF IGTWPKEKRS
SVHGVSFDIS FDKEDDVQRS TPNRGMTRSV SNEGLTLNNS RGSKHIRKNL SFKPVNGEEE
AESIEEELNA DSHSDLKSYM PLNRNNLNAN ENIHYKLPNG ALQNRVLLDE FANQIETPSI
EEALQIIHDT EKPPHTPQPD QVANGFFLHN QELSLLNSNI KLNQSSPDNM TDIKGALSPI
TDNTEVDTGI HVPSEDIPET MDEDSSLRDY TVSLDSDMDD ASKFLQDYDL RTCNPRESLS
PCPSTVSTKS QPGSSASSSS GVKMTSFAEQ KFRKLNHTDG KSSGSSSQKT TPEGSELNIP
HVVAWAQIPE ETGLPQGRDT TQLLASEMVH LRMKLEEKRR TIEAQKKKME AAFTKQRQKM
GRTAFLTVVK KKGDGISPLR EEAAGAEDEK VYTDRTKEKD SQKAHGQRSK SLADIKESLE
SPQPKWLKSP TTPVDPEKQW NLASPSEENL NEGEMIEYTK SIEKLNSSLH FLQQEMQRLS
LQQEMLMQMR EQQSWVISPP QPSPQKQSRD FKSSRQTGLS SAVAPFSSDS PRPTHPSPQS
SNRKSASFSA KSQRTPRPNE LKITPLNRTL TPPRSVDSLP RLRRFSPSQV PIQTRSFVCF
GDDGEPQLKE SKPKEAVKTE ELESKETVEQ QGQNSEGKKI RPLESTVSEV LSQPITETVC
LTPNEDQLSQ STEPHSKPIF PPPAPKTVNL IEVSLSDLKP PENTDVAVEK YDGESDKEQF
DDDQKVCCGF FFKDDQKAEN DMAMKRAALL EKRLRREKET QLRKQQLEAE MEHKKEETRR
KTEEERQKKE DERARREFIR QEYMRRKQLK LMEDMDTVIK PRPQIAKQKK PRPKSIHRDH
VESPKTPVKG PPGSRLYRVF SVSSLSLASL NTGDTESVQS GKQTPRSESV EGFLSPSRCG
SRNGEKDWEN ASTTSSVASG TEYTGPKLYK EPSAKSNKHI IQNALAHCCL AGKVNEGQKK
KILEEMEKSD ANNFLILFRD SGCQFRSLYT YCPETEEINK LTGIGPKSIT KKMIEGLYKY
NSDRKQFSHI PAKTLSASVD AITIHSHLWQ TKRPVTPKKL LTH
//
