ID A0A1S3WDF0_ERIEU Unreviewed; 1867 AA.
AC A0A1S3WDF0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|RefSeq:XP_016044413.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016044413.1};
RN [1] {ECO:0000313|RefSeq:XP_016044413.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_016044413.1; XM_016188927.1.
DR CTD; 5802; -.
DR eggNOG; KOG4228; Eukaryota.
DR InParanoid; A0A1S3WDF0; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016044413.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1867
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010259288"
FT TRANSMEM 1218..1241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..406
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 411..505
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..598
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 603..700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 705..813
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 814..914
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 918..1021
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1312..1567
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1487..1558
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1599..1858
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1776..1849
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 128..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1867 AA; 206043 MW; 8089C04C79642FFE CRC64;
MLLGWGTGVA SAMGPLGLLV MLLAGGCAAE EPPRFTKEPK DQIGVSGGVA SFVCQATGDP
KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NAVGEVTVHA
KLTVLRGARR PGVGGPSPSD SRTRLGTRDG PPWTPPLPCV SGPCRGSPDR PGFVSPPLPA
GALQIESSEE TDQGKYECVA ANSAGVRYSS PANLYVRELR EVRRVAPRFS ILPMSHEIMP
GGNVNITCVA VGSPMPYVKW MQGAEDLTPE DDMPVGRNVL ELTDVKDSAN YTCVAMSSLG
VIEAVAQITV KSLPKAPGTP VVTENTATSI TITWDSGNPD PVSYYVIEYK SKSQDGPYQI
KEDITTTRYS IGGLSPNSEY EVWVSAVNSI GQGPPSEAVV TRTGEQAPAS APRNVQARML
SASTMIIQWE EPVEPNGLVR GYRVYYTMEP QHPVSSWQKH NVDDSLLTTV GSLLEDETYT
VRVLAFTSVG DGPLSEPIQV KTQQGVPGQP MNFRAEAKSE TSISLSWSPP RQETVTKYEL
VFREGDAGTE IHRTFDPATA FEVDGLKPNT EYTFRLAARS VQGVGAFTSP LRQRTLESKP
SAPPQDVQGV STRSTAIVVS WRPPPAEAQH GALVGYSVHY RALDADPAED QAVTGIPPTA
SRILLAALRK WTRYRITAAA HTRAGAGPQS APVLVRTDED VPSAPPRKVE VEALNATAIR
VLWRSPPPDR QHGQIRGYQV HLARIDGTEA RGPPSIRDVM LADAQWEKDD TAEYEMVITD
LQPETTYSIT VAAYTLKGDG ARSKPKVVTT KSPVLGRPWL SLQLSPEGAV LARWAPPPGT
EDGVLSYRLR FWPQGDEDGD AAGDASTLEL PAQQLSHTAR GLAPGATYQF RLAARGRGGP
GEEAAATLAL PEDAPRGHPR VLGAAGDARA GTVLLRWLPP APAERGGSVL KYTVSVLPED
PPGPPRETEV AAAPRPGAET ALTLRGLEPN TTYQLRVRAH TARGAGPYSP PVRYHTFLRD
PVSPKNFKVK MIMKTSVLLG WEFPDNYNSP TPYKVGARPM GGGLWSGGGT LGVGDMPVPH
SLSIPDRSYF IVMVPLRKSR GGQFLTPLGS PEDMDLEELI QDVARLQRRS LRHSRQLEVP
RPYIAARFSV LPPTFHLGDQ KQYGGFDNHG LEPGHRYVLF VLAVLQKSEP TFAASPFSDA
FQLDNPDPQP IVDGEEGLIW VIGPVLAVVF IICIVIAILL YKNKPDSKRK DSEPRTKCLL
NNSDLAPHHP KDPVEMRRMN FQTPGMLNHP PIPIADMAEH TERLKANDSL KLSQEYESID
PGQQFTWEHS NLEVNKPKNR YANVIAYDHS RVILQPIEGI VGSDYINANY VDGYRRQNAY
IATQGPLPET FGDFWRMVWE QRSATIVMMT RLEEKSRIKC DQYWPNRGTE TYGFIQVTLL
DTIELATFCV RTFSLHKNGS SEKREVRQFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD
AGPIVVHCSA GVGRTGCFIV MDAMLERLRP ERSVDVYGHV TLMRAQRNYM VQTEDQYSFI
HDALLEALGC GATEVPARSL CAYLQRLGAT EPGQQASGME LEFKRLANSK AHTSRFVSAN
LPCNKFKNRL VNIMPYESTR VCLQPIRGVE GSDYINASFV DGYRQQKAYI ATQGPLAETT
EDFWRMLWEN NSTIVVMLSK LRELGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR
EFKVTDARDG QSRTVRQFQF TDWPEQGVPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS
AGVGRTGVFI TLSIVLERMR YEGVVDIFQT VKMLRTQRPA MVQTEDEYQF CYQAALEYLG
SFDHYAT
//
