ID A0A1S3WDL2_ERIEU Unreviewed; 1935 AA.
AC A0A1S3WDL2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|RefSeq:XP_016044377.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016044377.1};
RN [1] {ECO:0000313|RefSeq:XP_016044377.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016044377.1; XM_016188891.1.
DR CTD; 5789; -.
DR InParanoid; A0A1S3WDL2; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14628; R-PTP-D-2; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016044377.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1935
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010222970"
FT TRANSMEM 1272..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 329..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 424..520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 522..611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 616..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..826
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 827..920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 925..1020
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1380..1635
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1555..1626
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1667..1926
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1844..1917
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1303..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1935 AA; 217163 MW; C932204B24D90DF2 CRC64;
MLLPSCRMVH VASPLLLLLT FFLRVDAETP PRFTRTPVDQ TGVSGGVASF ICQATGDPRP
KIVWNKKGKK VSNQRFEVIE FDDGSGSVLR IQPLRTPRDE AIYECVASNN VGEISVSTRL
TVLREDQIPR GFPTIDMGPQ LKVVERTRTA TMLCAASGNP DPEITWFKDF LPVDTSNNNG
RIKQLRSGGT PIRGALQIEQ SEESDQGKYE CVATNSAGTR YSAPANLYVR ELREVRRVPP
RFSIPPTNHE IMPGGSVNIT CVAVGSPMPY VKWMLGAEDL TPEDDMPIGR NVLELNDVRQ
SANYTCVAMS TLGVIEAIAQ ITVKALPKPP GTPIVTESTA TSITLTWDSG NPEPVSYYII
QHKPKNSEEP YKEIDGVATT RYSVAGLSPY SDYEFRVVAV NNIGRGPPSE PVLTQTSEQA
PSSAPRDVQA RMLSSTTILV QWKEPEEPNG QIQGYRVYYT MDPTQHVNNW MKHNVADSQI
TTIGNLVPQK TYSVKVLAFT SIGDGPLSSD IQVITQTGVP GQPLNFKAEP ESETSILLSW
TPPRSDTIAN YELVYKDGDL GEEQRITIEP GTSYRLQGLK PNSLYYFRLA ARSPQGLGAS
TAEISARTMQ SKPSAPPQDI SCTSPSSTSI LVSWQPPPVE KQNGIITEYS IKYTAIDGED
DKPREILGIP SDTTKYLLEQ LEKWTEYQIT VTAHTDVGPG PESLSVFIRT DEDVPSGPPR
KVEVEAVNST SVKVSWRSPV PNKQHGQIRG YQVHYVRMEN GEPKGQPMLK DVMLADAQWE
FDDTTEHDMI ISGLQPETSY SLTVTAYTTK GDGARSKPKL VSTTGAVPGK PRLVINHTQM
NTALIQWHPP VDIFGPLLGY RLKYGRKDME PLTTLEFSEK EDHFTAIDIH KGASYVFRLS
ARNKVGFGEE MVKEISVPEE VPSGFPQNLH SEGTTSTTVQ LSWQPPVLAE RNGIITKYTL
LYRDINIPLL PMEQLIVPAD TTMTLSGLKP DTTYDVKVRA YTSKGPGPYS PSVQFRTLPV
DQAVFAKNFH VKAVMKTSVL LSWEIPENYN SAMPFKILYD DGKMVEEVDG RATQKLIVNL
KPEKSYSFVL TNRGNSAGGL QHRVTAKTAP DVLRTKPAFI GKTNLDGMIT VQLPEVPENE
NIKGYYIIIV PLKKSRGKFI KPWESPDEME LDELLKEISR KRRSVRYGRE VELKPYIAAH
FDVLPTEFTL GDDKHYGGFT NKQLQSGQEY VFFVLAVMEH AESKMYATSP YSDPVVSMDL
DPQPITDEEE GLIWVVGPVL AVVFIICIVI AILLYKSKPD RKRAESDSRK SSIPNSKEVP
SHHPTDPVEL RRLNFQTPGS DDSGYRGNLH SSSMASHPPI PILELADHIE RLKANDNLKF
SQEYESIDPG QQFTWEHSNL EVNKPKNRYA NVIAYDHSRV LLSAIEGIPG SDYVNANYID
GYRKQNAYIA TQGSLPETFG DFWRMIWEQR SATVVMMTKL EERSRVKCDQ YWPTRGTETH
GLVQVTLLDT VELATYCVRT FALYKNGSSE KREVRQFQFT AWPDHGVPEH PTPFLAFLRR
VKTCNPPDAG PMVVHCSAGV GRTGCFIVID AMLERIKHEK TVDIYGHVTL MRAQRNYMVQ
TEDQYIFIHD ALLEAVTCGN TEVPARNLYA YIQKLTQIET GENVTGMELE FKRLASSKAH
TSRFISANLP CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFIDG YRQQKAYIAT
QGPLAETTED FWRMLWEHNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ YFVVDPMAEY
NMPQYILREF KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV HKTKEQFGQD
GPISVHCSAG VGRTGVFITL SIVLERMRYE GVVDIFQTVK MLRTQRPAMV QTEDQYQFCY
RAALEYLGSF DHYAT
//
