ID   A0A1S3WF46_ERIEU        Unreviewed;      1057 AA.
AC   A0A1S3WF46;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   Name=MAN2C1 {ECO:0000313|RefSeq:XP_016044902.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016044902.1};
RN   [1] {ECO:0000313|RefSeq:XP_016044902.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_016044902.1; XM_016189416.1.
DR   AlphaFoldDB; A0A1S3WF46; -.
DR   GeneID; 103115929; -.
DR   CTD; 4123; -.
DR   InParanoid; A0A1S3WF46; -.
DR   OrthoDB; 2786490at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10813; GH38N_AMII_Man2C1; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          516..595
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1057 AA;  117133 MW;  A4A61C76A68A6536 CRC64;
     MAAAPLKHRR TTLERVEKFV SPLYFTDCNL RGRLFGDSCP VAALSSFLTP ERLPYQEAIQ
     QDFRPAQVGD SFGPTWWTCW FRVELSIPEA WLGQEVHLLW ESDGEGLVWR DGEPVQGLTK
     EGEKTSYVLT DKLREEDSRS LTLYVEVACN GLLGAGKGSM IAAPDPEKMF QVNRAELAVF
     RRDVHKLLVD LELLLGIAKG LGEDNQRSFQ ALYTANQIIN ICDPAQPETF PAAHALASRF
     FDQRGGESQH TLHAVGHCHI DTAWLWPFKE TVRKCARSWV TAVNLMERNP EFIFACSQAQ
     QLEWVRNHYP GLYTRIQEFF QRGQFVPVGG TWVEMDGNLP SGEAMVRQFL QGQNFFLQEF
     GEMCSEFWLP DTFGYSAQLP QIMRNCGIKY FLTQKLSWNL VNSFPHHTFF WEGLDGSRVL
     AHFPPGDSYG MQGSVEEVLK TVTKNQDKGR TNHSAFLFGF GDGGGGPTQT MLDRLKRLSN
     TDGLPRVQLS SPKQLFLKLE GSSEQLCTWV GELFLELHNG TYTTHAQIKK GNRDCERILH
     DVELVSSLAL ARSTQFLYPA AQLQELWRLL LLNQFHDVVT GSCIQLVVEE AMAHYKDIRS
     QGGALLSAAA TALCAGEPGP GGLLIVNTLP WKRTEVLALP RPGGSHSLGT LGESPGDSAQ
     HGLCTCSRAH LPAASAAPAA CVCGARGSFS STSRPALTKT DGSVTLDNGI IRVKLNPTGC
     LTSLVLVASG REAIAEGAVG NQFVLFDDVP LYWDAWDVMD YHLETRKPVP GQAGTLAVGA
     EGGLRGSAWF LLQLSPNSRL SQEVVLDVGC PYVRFHTEVH WHESHKFLKV EFPAHVRSSQ
     ATYEVQFGHL QRPTHKNTSW DWARYEVWAH RWMDLSEHGF GLALLNDCKY GASVHGSVLS
     LSLLRAPKAP DATADMGRHE FTYALMPHKG SFQDAGVIQA AYNLNFPLLA LPAPGRAPAT
     AWSAFSVSTS AVVLETVKQA ESCPQGRTLV LRLYEAHGSH VDCWLRTSLL VQEAVLCDLL
     ERRDSAGYLP LQENGLKLTF SPFQVRSLLL VLQPSLS
//