ID   A0A1S3WHE2_ERIEU        Unreviewed;      1090 AA.
AC   A0A1S3WHE2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6 {ECO:0000313|RefSeq:XP_016045798.1};
GN   Name=CACNA2D1 {ECO:0000313|RefSeq:XP_016045798.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016045798.1};
RN   [1] {ECO:0000313|RefSeq:XP_016045798.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   RefSeq; XP_016045798.1; XM_016190312.1.
DR   AlphaFoldDB; A0A1S3WHE2; -.
DR   CTD; 781; -.
DR   OrthoDB; 2971287at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1090
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010186443"
FT   DOMAIN          253..430
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1090 AA;  123284 MW;  67ECFF681F5486D8 CRC64;
     MAARCLLALT LTLFQFLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI
     YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AQEAERVQAA HQWREDFASN
     EVVYYNAKDD LDSEKNDSEP GSQRIKPVFT EDANFGRQIS YQHAAVHIPT DIYEGSTIVL
     NELNWTSALD EVFKKNQEED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR
     RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD
     VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML
     FTDGGEERAQ EIFTKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR
     INTQEYLDVL GRPMVLAGEK AKQVQWTNVY LDALELGLVI TGTLPVFNIT GQVENKTKNQ
     LILGVMGVDV SLEDIKRLTP RFTLCPNGYY FAIDPNGYVL LHPNLQPKNP KSQEPVTLDF
     LDAELENDIK VEIRNKMIDG ESGDRTFRTL VKSQDERYID KGNRTYTWTP VNGTDYRYLA
     LVLPTYSFYY IKAKIEETIT QARSKKGKMK DSETLKPDNF EESGYTFIAP RDYCNDLKIS
     ENNTEFLLNF NEFIDRKTPN NPSCNTDLIN RVLLDAGFTN ELVQNYWSKQ KNIKGVKARF
     VVTDGGITRV YPKEAGENWQ ENPETYEDSF YKRSLDNDNY VFTAPNFNKS GPSAYESGIM
     VSKAVEIYIQ GKLLKPAVVG IKIDVNSWIE NFTKTSIRDP CAGPVCDCKR NSDVMDCVIL
     DDGGFLLMAN HDDYTNQIGR FFGEIDPSLM RHLINISVYA FNKSYDYQSV CDPGAAPKQG
     AGHRSAYVPS IADILHIGWW ATAAAWSILQ QLLLSLTFPR LLEAVELEDE DFASPLSKQS
     CITEQTQYFF DNDSKSFSGV LDCGNCSRIF HVEKLMNTNL IFIMVESKGT CPCDTRQLIQ
     AEQTSDGPDP CDMVKKPRYR KGPDVCFDNN VLEDYTDCGG VSGLNPSLWS IIGIQFVLLW
     LLSGSKHCQL
//