ID A0A1S3WHL1_ERIEU Unreviewed; 393 AA.
AC A0A1S3WHL1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Homeobox protein Meis2 isoform X7 {ECO:0000313|RefSeq:XP_016045777.1};
GN Name=MEIS2 {ECO:0000313|RefSeq:XP_016045777.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016045777.1};
RN [1] {ECO:0000313|RefSeq:XP_016045777.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
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DR RefSeq; XP_016045777.1; XM_016190291.1.
DR AlphaFoldDB; A0A1S3WHL1; -.
DR CTD; 4212; -.
DR OrthoDB; 3180467at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF47; HOMEOBOX PROTEIN MEIS2; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000313|RefSeq:XP_016045777.1};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 273..336
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 275..337
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 192..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 42950 MW; 781E847ECACD1EF1 CRC64;
MFLYDELPHY GGMDGVGVPA SMYGDPHAPR PIPPVHHLNH GPPLHATQHY GAHAPHPNVM
PASMGSAVND ALKRDKDAIY GHPLFPLLAL VFEKCELATC TPREPGVAGG DVCSSDSFNE
DIAVFAKQVR AEKPLFSSNP ELDNLMIQAI QVLRFHLLEL EKVHELCDNF CHRYISCLKG
KMPIDLVIDE RDGSSKSDHE ELSGSSTNLA DHNPASWRDH DDATSTHSAG TPGPSSGGHA
SQSGDNSSEQ GDGLDNSVAS PGTGDDDDPD KDKKRQKKRG IFPKVATNIM RAWLFQHLTH
PYPSEEQKKQ LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRAVSQGAA YSPEGQPMGS
FVLDGQQHMG IRPAGPMSGM GMNMGMDGQW HYM
//
