ID A0A1S3WHT7_ERIEU Unreviewed; 660 AA.
AC A0A1S3WHT7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO3A1 {ECO:0000313|RefSeq:XP_016045953.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016045953.1};
RN [1] {ECO:0000313|RefSeq:XP_016045953.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_016045953.1; XM_016190467.1.
DR AlphaFoldDB; A0A1S3WHT7; -.
DR STRING; 9365.ENSEEUP00000011215; -.
DR GeneID; 103108583; -.
DR CTD; 28232; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd17402; MFS_SLCO3_OATP3; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF86; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 3A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 29..52
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 126..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 164..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 487..513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 525..548
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 416..464
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 660 AA; 71379 MW; B4C53C0267550218 CRC64;
MLAQGTVGAY LVSVLTTLER RFNLQSADVG VIASSFEIGN LALILFVSYF GARGHRPRLI
GCGGIVMALG ALLSALPEFL THQYKYEAGE IRWAAEGRDV CAANGSRGDQ GPDPDLICRS
RTATNMMYLL LIGAQVLLGI GATPVQPLGV SYIDDHVRRK DSSLYIGILF TMLVFGPACG
FILGSFCTKI YVDAVFIDTS SLDITPDDPR WIGAWWGGFL LCGALLFFSS LLMFGFPQSL
PLHSDPAMES EQAMLPEREY EHPKPSNGVL RHPLEPDSSA SCFQQLRVIP KVTKHLLSNP
VFTCIILAAC MEIAVVAGFA AFLGKYLEQQ FNLTTSSANQ LLGMTAIPCA CLGIFLGGLL
VKKLSLSALG AIRMAMLVNL VSTACYVSFL FLGCDTGPVA GVTVPYGNTS ASGAALDPYS
PCNKNCECQT DSFTPVCGAD GITYLSACFA GCNSTNLTGC ACLTTIPPEN ATVVPGKCPS
PGCQEAFLTF LCVMCVCSMI GAMAQTPSVI ILIRTVSPEL KSYALGVLFL LLRLLGFIPP
PLIFGAGIDS TCLFWSTFCG EKGACALYDN VAYRYLYVSI AITLKAFAFL LYTTTWQCLR
KNYKRYIKNH EGGLTTSEFF ASTLTLENLG RDPVPHQTHR TKFIYNLEDH EWCENMESVL
//
