ID A0A1S3WIF9_ERIEU Unreviewed; 2055 AA.
AC A0A1S3WIF9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Citron Rho-interacting kinase {ECO:0000256|PIRNR:PIRNR038145};
DE EC=2.7.11.1 {ECO:0000256|PIRNR:PIRNR038145};
GN Name=CIT {ECO:0000313|RefSeq:XP_016046125.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016046125.1};
RN [1] {ECO:0000313|RefSeq:XP_016046125.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in cytokinesis. Displays serine/threonine
CC protein kinase activity. {ECO:0000256|PIRNR:PIRNR038145}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433,
CC ECO:0000256|PIRNR:PIRNR038145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|PIRNR:PIRNR038145};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR038145}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|PIRNR:PIRNR038145}.
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DR RefSeq; XP_016046125.1; XM_016190639.1.
DR GeneID; 103118398; -.
DR CTD; 11113; -.
DR OrthoDB; 3490126at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd20814; CRIK; 1.
DR CDD; cd05601; STKc_CRIK; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR017405; Citron_Rho-interacting_kinase.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR037708; CRIK_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988:SF71; CITRON RHO-INTERACTING KINASE; 1.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF038145; Citron_Rho-interacting_kinase; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR038145};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR038145};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR038145};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR038145};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 97..361
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 362..432
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 1391..1440
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1472..1592
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1620..1910
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1319..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1933..2040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 459..589
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 626..750
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 776..1241
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1979..2027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2055 AA; 234599 MW; A3DF0A56BC0DB159 CRC64;
MLKFKYGTRN PQDVGAAEPI TSRASRLNLF FQGKPPFMTQ QQVSPLSREG VLDALFVLFE
ECSQPAMMKM KHVNNFVRKY SDTIAELQGL QPSAKDFEVR SLVGCGHFAE VQVVREKATG
DIYAMKVMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKSNL YLVMEYQPGG
DLLSLLNRYE DQLDENMIQF YLAELILAVH SIHQMGYVHR DIKPENILID RTGHLKLVDF
GSAAKLNSNK MVTAKLPIGT PDYMAPEVLT VMNGDGKGAA YGPDCDWWSV GVITYEMIYG
RTPFTEGTSA RTFNNIMNFQ RFLKFPDDPK VSSTLLDLIQ SLLCGQKERL KFEGLCCHPF
FSKIDWNNIR NTPPPFVPTL KSDDDTSNFD EPEKNLWVSS SACQLSPSGF SGEELPFVGF
SYSKALGILG RSESVVSGLD SPAKTSSMEK KLLIKSKELQ DSQDKCHKME QEMTRLHRRV
SEVEAVLSQK EVELKASETQ RSLLEQDLAT YITECSSLKR SLEQARMEVS QEDDKALQLL
HDIREQSRKL QEIKEQEYQA QVEEMRLMMN QLEEDLVSAR RRSDLYESEL RESRLAAEEF
KRKATECQHK LVKAAKDPGK PEVGEYSKLE KINAEQQIKI QELQEKLEKA VKASTEAAEL
LQNIRQAKER AERELEKLQN REDSSEGIKK KLVEAEERRH SLENKVKRLE TMERRENRLK
DDIQTKSQQI QQMADKILEL EEKHREAQVS AQHLEVHLKQ KEQHYEEKIK VLDSQIKKDL
ADKESLENLM QRHEEEAHEK GKILSEQKAM INAMDSKIRS LEQRIVELSE ANKLAANSSL
FTQRNMKAQE EMISELRQQK FYLETQAGKL EAQNRKLEEQ LEKISHQDHS DKSRLLELET
RLREVSLEHE EQKLELKRQL TELQLSLQER ESQLTALQSA RAALEGQLRQ AKTELEETTA
EAEEEIQALT AHRDEIQRKF DALRNSCTVI TDLEEQLNQL TEDNAELNNQ NFYLSKQLDE
ASGANDEIVQ LRSEVDHLRR EITEREMQLT SQKQTMEALK TTCTMLEEQV MDLEALNDEL
LEKERQWEAW RSVLGDEKSQ FECRVRELQR MLDTEKQSRA RADQRITESR QVVELAVKEH
KAEILALQQA LKEQKLKAES LSDKLNDLEK KHAMLEMNAR SLQQKLETER ELKQRLLEEQ
AKLQQQMDLQ KSHIFRLTQG LQEALDRADL LKTERSDLEY QLENIQVLYS HEKVKMEGTI
SQQTKLIDFL QAKMDQPAKK KKVPLQYNEL KAALEKEKAR CAELEEALQK TRIELRSARE
EAAHRKATEH PHPSTPATAR QQIAMSAIVR SPEHQPSAMS LLAPPSGRRK ESSTPEEFSR
RLKERMHHNI PHRFNVGLNM RATKCAVCLD TVHFGRQASK CLECQVMCHP KCSTCLPATC
GLPAEYATHF TEAFCRDKMN SPGLQTKEPS SGLHLEGWMK VPRNNKRGQQ GWDRKYIVLE
GSKVLIYDSE AREAGQRPVE EFELCLPDGD VSIHGAVGAS ELANTAKADV PYILKMESHP
HTTCWPGRSL YLLAPSFPDK QRWVTALESV VAGGRVSREK AEADAKLLGN SLLKLEGDDR
LDMNCTLPFS DQVVLVGTEE GLYALNVLKN SLTHVPGIGA VFQIYIIKDL EKLLMIAGEE
RALCLVDVKK VKQSLAQSHL PAQPDISPNV FEAVKGCHLF AAGKIESGLC ICAATPSKVV
ILRYNENLSK YCIRKEIETS EPCSCIHFTN YSVLIGTNKF YEIDMKQYTL EEFLDKNDHS
LAPAVFASSS NSFLVSIVQV NGAGQREEYL LCFHEFGVFV DSYGRRSRTD DLKWSRLPLA
FAYREPYLFV THFNSLEVIE IQARSSLGTP ARAYLEIPNP RYLGPAISSG AIYLASSYQD
KLRIICCKGN LVKESGTDHH RGPSTSRSPN KRGPPTYNEH ITKRVASSPA PPEGPSHPRE
PSTPHRYREG RTELRRDKSP GRPLEREKSP GRVLSTRRER SPGRLFEDSS RGRLPAGAVR
TPLSQVNKVW DQSSV
//
