ID A0A1S3WIG4_ERIEU Unreviewed; 636 AA.
AC A0A1S3WIG4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein R isoform X1 {ECO:0000313|RefSeq:XP_016046129.1, ECO:0000313|RefSeq:XP_016046130.1};
GN Name=HNRNPR {ECO:0000313|RefSeq:XP_016046129.1,
GN ECO:0000313|RefSeq:XP_016046130.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016046130.1};
RN [1] {ECO:0000313|RefSeq:XP_016046129.1, ECO:0000313|RefSeq:XP_016046130.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_016046129.1; XM_016190643.1.
DR RefSeq; XP_016046130.1; XM_016190644.1.
DR STRING; 9365.ENSEEUP00000009244; -.
DR CTD; 10236; -.
DR eggNOG; KOG0117; Eukaryota.
DR OrthoDB; 3184171at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21067; NURR_hnRNPR; 1.
DR CDD; cd12482; RRM1_hnRNPR; 1.
DR CDD; cd12488; RRM2_hnRNPR; 1.
DR CDD; cd12494; RRM3_hnRNPR; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR041337; hnRNP_Q_AcD.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR034410; hnRNPR_RRM1.
DR InterPro; IPR034411; hnRNPR_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF5; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN R; 1.
DR Pfam; PF18360; hnRNP_Q_AcD; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Ribonucleoprotein {ECO:0000313|RefSeq:XP_016046129.1,
KW ECO:0000313|RefSeq:XP_016046130.1};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 165..244
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 246..331
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 344..414
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 71213 MW; 34BBCEDE03823AC1 CRC64;
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGAQ PGIGTEVFVG KIPRDLYEDE
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC
ISVANNRLFV GSIPKNKTKE NILEEFSKVT GLTEGLVDVI LYHQPDDKKK NRGFCFLEYE
DHKSAAQARR RLMSGKVKVW GNVVTVEWAD PVEEPDPEVM AKVKVLFVRN LATTVTEEIL
EKSFSEFGKL ERVKKLKDYA FVHFEDRGAA VKAMDEMNGK EIEGEEIEIV LAKPPDKKRK
ERQAARQASR NTAYEDYYYH PPPRMPPPIR GRGRGGGRGG YGYPPDYYGY EDYYDDYYGY
DYHDYRGGYE DPYYGYDDGY AVRGRGGGRG GRGAPPPPRG RGAPPPRGRA GYSQRGAPLG
PPRGSRGGRG GPAQQQRGRG SRGSRGNRGG NVGGKRKADG YNQPDSKRRQ TNNQQNWGSQ
PIAQQPLQQG GDYSGNYGYN NDNQEFYQDT YGQQWK
//
