ID A0A1S3WIM4_ERIEU Unreviewed; 906 AA.
AC A0A1S3WIM4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2 {ECO:0000313|RefSeq:XP_016046132.1};
GN Name=ASAP3 {ECO:0000313|RefSeq:XP_016046132.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016046132.1};
RN [1] {ECO:0000313|RefSeq:XP_016046132.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016046132.1; XM_016190646.1.
DR AlphaFoldDB; A0A1S3WIM4; -.
DR GeneID; 103118498; -.
DR CTD; 55616; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR CDD; cd17900; ArfGap_ASAP3; 1.
DR CDD; cd07640; BAR_ASAP3; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR047006; ASAP3_ArfGap.
DR InterPro; IPR028775; BAR_ASAP3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 302..394
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 427..549
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 586..621
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 622..654
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 695..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 99951 MW; ACAEB2E735DFE078 CRC64;
MPKQFSVAEF LAVTVEDLSS PAGAAAFVAK MPRCRGAVLA REEILEGDQA ILQRIKKAVR
MIHSSGLGHV ENEEQYQEAV ESLGNSHLSQ NSHELSTGFL NLSVFTREVA ALFKNLVQNL
NNIVSFPLDS LLKGQLRDGR QDSKKQLEKA WKDYETKMTR LEKERDRARM SGGSPGELAH
DTQRERRVFQ LHMCEYLLKA KESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLSPFI
EKLAVSVHAL RQAQEEELQN LTQLRDSLRG TLQLESREEN LNRKNSGGGY SIHQHQGNKQ
FGTEKVGFLY KKSDGIRRVW QKRKCGIKYG CLTISHSTIN RPPVKLTLLT CQVRPNLEEK
KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA FLGEPSSSSL GPWGSAGLQG
EPQDLTKLLI AEVKNRPGNN QCCDCGAADP TWLSTNLGVL TCIQCSGVHR ELGVRFSRMQ
SLTLDLLGSS ELLLALNIGN TCFNEIMEAQ LPSHSGPKPS AESNMSARRD YIVAKYVEHR
FARRSTLEPQ RLQMAICNQD LLSVLEAFAN GQDFRQPLLE PEGQAPGELA LHLAIRVANQ
TSLPLVDFII QNGGHLDAKA ADGNSALHCA ALYNQPDCLK LLLKGRASVG SVNDSGETAL
DIARKKQHKE CEELLEQAQA GTLAFPLHLD YSWEISTEPG SDSGEDEEEK QLCPLKPPTL
AHWTNVRLDI SNKTYETITS LAPTAPQSQS EDFPPPLPVK NPSRSVVQER AGHGSRDWLE
APSLSLEPFG VPENLSSPGS SSSSLMSPVE PGGPSKTLPG SEEGPRESPG PSKPSLISGT
TLAETYHPVR FSSESTRSYR RGGRSLEDSS SSRQPLLKRN MPVGITEGDS SRAGGLPSSS
MQPLQD
//
