ID A0A1S3WJ41_ERIEU Unreviewed; 1041 AA.
AC A0A1S3WJ41;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ULK1 {ECO:0000313|RefSeq:XP_016046403.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016046403.1};
RN [1] {ECO:0000313|RefSeq:XP_016046403.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016046403.1; XM_016190917.1.
DR AlphaFoldDB; A0A1S3WJ41; -.
DR GeneID; 103119043; -.
DR CTD; 8408; -.
DR OrthoDB; 8335at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006914; P:autophagy; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR CDD; cd14202; STKc_ULK1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR048941; ATG1-like_MIT2.
DR InterPro; IPR022708; Atg1-like_tMIT.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR PANTHER; PTHR24348:SF19; SERINE_THREONINE-PROTEIN KINASE ULK1; 1.
DR Pfam; PF12063; ATG1-like_MIT1; 1.
DR Pfam; PF21127; ATG1-like_MIT2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|RefSeq:XP_016046403.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 15..277
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 283..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1041 AA; 111829 MW; D9F4AF6589B1E1E9 CRC64;
MEPRGGLETV GKFEFSRKDL IGHGAFAVVF KGRHREKHDL EVAVKCINKK SLAKSQTLLG
KEIKILKELK HENIVALYDF QEMANSVYLV MEYCNGGDLA DYLHTMRTLS EDTIRLFLQQ
IVGAMRLLHS KGIIHRDLKP QNILLSNPGG RRANPNNIRV KIADFGFARY LQSNMMAATL
CGSPMYMAPE VIMSQHYDGK ADLWSIGTIV YQCLTGKAPF QASSPQDLRL FYEKNKTLVP
TIPRETSAPL RQLLLSLLQR NHRDRMDFDE FFHHPFLDAS AAVKKSPPVP VPSYPSSGSG
SSSSSSSTSH LASPPSLGDM QQLQKTLISP AEAAGFLQGS RDSGGSSKDS CDTDDFVMVP
AQFAGDLVAE VAGSRPPPDS LMCSGSSLVA SAGLESHGQT PSPSPPCSSS PSPSGRCGAS
VPIPVPTQLH NYQRIEQNLQ SPAHCQTSRS STVRRSGSAS PLGFTRASLS PPTHVEHGAA
LARKLSLGGG RPYTPSPQVG TIPERPGWSR VPSPQGAEIR AGRSPRSGSS VPEHSSHLTG
LGSRLHSAPN LSDLHVIRPK LPKPPTDPLG LTFSPPPASP PQLAPGLPPC RPLRGSPKLP
DFLQRNPLPP ILGSPTKAVS TLDFPKTPSS QNLLTLLARQ GVVVTPPRNR TLPDLSEAGP
LHGQPLGPGL RLPEDAKSPF GRSFSTGRLT DLLLKAAFGT QAPDSGSTDS LQERPMDVAP
SAGFGGSLHP GARAGGASSP APVVFTVGSP PSGTTPPQGP RTRMFSVGSS SSLSSAGSSS
ARHLVPAEAP PELPIPGHCC SFADPLTVNL EGAVTFEAPD LPEETLMEQE HTEILHSLRF
TLVFAEHILE MAALKGSASE AAGGPEFQLQ ESVVADQISL LSREWGFAEQ LVLYLKVAEL
LSAGLQTAIE QIRAGKLCLS STVKQVVREL NELYKASVVS CEGLSLRLQR FFMDKHRLLD
RIQSVTAEKL IFSHAVQMVQ SAALDEMFHR REDCVQRYHK ALLLLEGLQH ILTDQADVES
IAKCKLCIER RLSALLTGIC P
//
