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Database: UniProt
Entry: A0A1S3WJP7_ERIEU
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ID   A0A1S3WJP7_ERIEU        Unreviewed;       430 AA.
AC   A0A1S3WJP7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 15.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 12 {ECO:0000313|RefSeq:XP_016046596.1};
GN   Name=KCNJ12 {ECO:0000313|RefSeq:XP_016046596.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016046596.1};
RN   [1] {ECO:0000313|RefSeq:XP_016046596.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   RefSeq; XP_016046596.1; XM_016191110.1.
DR   STRING; 9365.XP_007529727.1; -.
DR   GeneID; 103119393; -.
DR   CTD; 3768; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003272; K_chnl_inward-rec_Kir2.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF14; PTHR11767:SF14; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01325; KIR22CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_016046596.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     82    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    157    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4     46       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       47    187       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      194    365       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      387    430       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        173    173       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   430 AA;  48814 MW;  71A26F910D3273EB CRC64;
     MTTAGRANPY SIVSSEEDGL HLVTMSGANS FRNGKVHTRR RCRNRFVKKN GQCNIEFANM
     DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGV IFWIIAVAHG DLEPAEGQER
     TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI
     MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE
     GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE
     GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK
     DLVENKFLLP SASSFCYENE LAFLSRDEED EADAEQDSCS PQARHDFDRP QAGGSSSTLE
     QRPYRRESEI
//
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