ID A0A1S3WLZ5_ERIEU Unreviewed; 1500 AA.
AC A0A1S3WLZ5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 1 isoform X2 {ECO:0000313|RefSeq:XP_016047375.1};
GN Name=TRPM1 {ECO:0000313|RefSeq:XP_016047375.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016047375.1};
RN [1] {ECO:0000313|RefSeq:XP_016047375.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_016047375.1; XM_016191889.1.
DR CTD; 4308; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_016047375.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 738..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..242
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 745..991
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1086..1140
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 312..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1500 AA; 170373 MW; 2F8720E32521DE45 CRC64;
MVKEWHLELP KLLISVHGGL QNFEMQPKLK QVFGKGLIKA AMTTGAWIFT GGVSTGVISH
VGDALKDHSS KSRGRVCAIG IAPWGIVENK EDLIGKDVTR VYQTMSNPLS KLSLLNNSHT
HFILADNGTL GKYGAEVKLR RQLEKHVSLQ KINTRLGQGV PVVGLVVEGG PNVVSIVLEY
LREEPPVPVV VCDGSGRASD ILSFAHKLIN DSLKDQLLVT IQKTFNYNKA QSHQLFAIIM
ECMKKKELVT VFRMGSEGQQ DMEMAILTAL LKGTNASAPD QLSLALAWNR VDIARNQIFI
FGPHWPPLGS LAPPIDSKAT EKEKKPPTAT TKAGRGKGKG KKKGKVKEEV EEETDPRKIE
LLNWVNALEQ AMLDALVLDR VDFVKLLIEN GVNMQHFLTI PRLEELYNTR LGPPNTLHLL
VRDVKKGNLP PDYHISLIDI GLVLEYLMGG AYRCNYTRKS FRTLYNNLFG PKRPKALKLL
GMEDDEPPAK GKKKKKKKKE EEVDIDVDDP AVSRFQYPFH ELMLWAVLMK RQKMAVFLWQ
RGEESMAKAL VACKLYKSMA HESSESELVD DISQDLDNNS KDFGQLAVEL LDQSYKHDEQ
IAMKLLTYEL KNWSNSTCLK LAVAAKHRDF IAHTCSQMLL TDMWMGRLRV RKNPGLKVIL
GILLPPTILF LEFRTHDDFS YQTSKENEDG KDKEEENMDA NADAGSRKGD EENEHKKQRS
IPIGTKICEF YNAPIVKFWF YTISYLGYLL LFNYVILVRM DRWPCLQEWI VIAYILSLAL
EKIREILMSE PGKLSQKIKV WLQEYWNITD LVAISMFMIG AILRLQKQPY MGYGRVIYCV
DIIFWYIRVL DIFGVNKYLG PYVMMIGKMM IDMLYFVVIM LVVLMSFGVA RQAILHPDEE
PSWKLARNIF YMPYWMIYGE VFADQIDLYA MEINPPCGDN LFDEEGKRLP PCIPGAWLTP
AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHD RPVLPPPMII
LSHIYIIVMR LSGRCRKEKG DQDERDRGLK LFLSEEELKR LHEFEEQCVQ EHFQEKEDEE
QSSSAERIRV TCERVENMSM RLEEVNEREN FMKTSLQSMD LRLSQLEDLS TRMVTALESL
AGIDRAELLQ SRSRASSECE ATLLLRQSSL NSADGYSLFR YHFNGEELLF EDSAFRRKAC
SFRGREEKDP RARLEPENLA SLQLMSSTSS LATPDCRQPS SDHKENPSVL QLGPDQGLLA
NDDERQADAK REDSLTPNFH RTDSMHEQNR CDVQNTQLTV DSTEVQDTIS YPLGETKMQC
CPPDETRNTC TTMKSRSFIY SRGRKVVSGV NEWGAKYSSI RGPVSPSAVQ QWTTEWTYQV
QKITRSQSTE IPPFVSEAAM QAEYREQLTE PEGDYCSSET APHFFGGSLA ATGTIEKDNL
LLSVRSEPTP GFPALRSKSL HGHPRYAKAL QGTLDRTGQA SSAKDLAVAS GTTTKGQEGK
//
