ID A0A1S3WM06_ERIEU Unreviewed; 605 AA.
AC A0A1S3WM06;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Growth factor receptor-bound protein 7 isoform X2 {ECO:0000313|RefSeq:XP_016047164.1};
GN Name=GRB7 {ECO:0000313|RefSeq:XP_016047164.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016047164.1};
RN [1] {ECO:0000313|RefSeq:XP_016047164.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR RefSeq; XP_016047164.1; XM_016191678.1.
DR AlphaFoldDB; A0A1S3WM06; -.
DR GeneID; 103120584; -.
DR CTD; 2886; -.
DR OrthoDB; 3144731at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16140; RA_GRB7; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR046986; GRB7_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF25; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|RefSeq:XP_016047164.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 145..231
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 274..383
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 476..600
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 67727 MW; 7A74F2E05C666E46 CRC64;
MRDAAFPSQP GARLTPRPGE HPRWPCFLSA LNTGPAILPW GQPDVMELGL SPPLLNNSPE
ELYLSPGTPP RTPPPPDGPL SREVKRSQPL PIPAGRKLLR EEELRATSLP SIPNPFPELC
SPPSQSPILG GSSGTRGLLP RDASRPHVIK VYSEDGACRS VEVAAGATAR YVCEMLVQRA
HALSDENWGL VECHPQLALE RGLEDHESVV EVQAAWPIGG DSRFVFRKNF AKYELFKTSP
HSLFPEKMVS SCLDAKADTS HEDLIQNFLN AGSFPEIQGF LQLRGSGRKL WKRFFCFLRR
SGLYYSTKGT SKDPRHLQCV ADVNESSVYV VTQGRKLYGM PTDFGFCIKP NKLRNGHKGL
HIFCSEDEQS RTCWLAAFRL FKYGVQLYKN YQLAQSRHLR PSYVGSPPLR SVSDNTLVAM
DFSGHAGRVI ENPREALSAA LEEAQAWRKK TNHRLSLPTP SSGSSLSAAI HRTQPWFHGR
ISREESQRLI GQQGLVDGLF LVRESQRNPQ GFVLSLCHLQ KVKHYLILPQ WGLQLWSPGE
PLQPQLPLTS CPLWSSQSEE EGRLYFSMDE GQTRFTDLLQ LVEFHQLNRG ILPCVLRHTC
TRVAL
//
