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Database: UniProt
Entry: A0A1S3WN80_ERIEU
LinkDB: A0A1S3WN80_ERIEU
Original site: A0A1S3WN80_ERIEU 
ID   A0A1S3WN80_ERIEU        Unreviewed;       432 AA.
AC   A0A1S3WN80;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN   Name=SLC1A3 {ECO:0000313|RefSeq:XP_016047589.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016047589.1};
RN   [1] {ECO:0000313|RefSeq:XP_016047589.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-
CC         aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in);
CC         Xref=Rhea:RHEA:71379, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:29103, ChEBI:CHEBI:29990;
CC         Evidence={ECO:0000256|ARBA:ARBA00036068};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) =
CC         H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in);
CC         Xref=Rhea:RHEA:70851, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:29103, ChEBI:CHEBI:29991;
CC         Evidence={ECO:0000256|ARBA:ARBA00037017};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) =
CC         H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in);
CC         Xref=Rhea:RHEA:70699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:29103, ChEBI:CHEBI:29985;
CC         Evidence={ECO:0000256|ARBA:ARBA00036463};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361216}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
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DR   RefSeq; XP_016047589.1; XM_016192103.1.
DR   AlphaFoldDB; A0A1S3WN80; -.
DR   GeneID; 103121519; -.
DR   CTD; 6507; -.
DR   OrthoDB; 49426at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR   Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 2.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   PANTHER; PTHR11958:SF24; EXCITATORY AMINO ACID TRANSPORTER 1; 1.
DR   PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR   Pfam; PF00375; SDF; 2.
DR   PRINTS; PR00173; EDTRNSPORT.
DR   SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361216};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361216};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
FT   TRANSMEM        123..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
FT   TRANSMEM        173..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
FT   TRANSMEM        202..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
FT   TRANSMEM        234..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361216"
SQ   SEQUENCE   432 AA;  46822 MW;  8A780D190126FA48 CRC64;
     MTKSNGEEPK AGGRVERFQQ GVRKRTLLAK KKVQSVTKED VRGCLVRNAF VLLTVSAVIV
     GTILGFALRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG
     MRAVVYYMTT TIIAVVIGIV VVIIIHPGKG TKEHMHREGK IVQVTAADAF LDLIRYAPLG
     ILFLIAGKIV EMEDMGVIGG QLAMYTVTVI VGLLIHGVIV LPLFYFLVTR KNPWVFIGGL
     LQALVTALGT SSSSATLPIT FKCLEENNGV DKRVTRFVLP VGATINMDGT ALYEALAAIF
     IAQVNNFDLN FGQIITISIT ATAASIGAAG IPQAGLVTMV IVLTSVGLPT DDITLIIAVD
     WFLDRLRTTT NVLGDSLGAG IVEYLSRHEL KSHDVELGNS VIEENEMKKS YQLVAQDSEP
     EKPGHGHGET KM
//
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