ID A0A1S3WPG2_ERIEU Unreviewed; 419 AA.
AC A0A1S3WPG2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 19 {ECO:0000313|RefSeq:XP_016048256.1};
GN Name=TNFRSF19 {ECO:0000313|RefSeq:XP_016048256.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048256.1};
RN [1] {ECO:0000313|RefSeq:XP_016048256.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_016048256.1; XM_016192770.1.
DR AlphaFoldDB; A0A1S3WPG2; -.
DR STRING; 9365.ENSEEUP00000011733; -.
DR GeneID; 103123066; -.
DR CTD; 55504; -.
DR eggNOG; ENOG502QQHI; Eukaryota.
DR InParanoid; A0A1S3WPG2; -.
DR OrthoDB; 5405444at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR CDD; cd13418; TNFRSF19; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022342; TNFR_19.
DR InterPro; IPR034047; TNFRSF19_N.
DR InterPro; IPR047526; TNR19/27/EDAR.
DR PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12120:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19; 1.
DR PRINTS; PR01969; TNFACTORR19.
DR SMART; SM00208; TNFR; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016048256.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..419
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010171875"
FT TRANSMEM 169..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..72
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 33..72
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 341..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 49..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 419 AA; 45539 MW; 3426A0B42E33DC78 CRC64;
MAFKGLLEQE KVLLTAAVLL ISLAQRGLCE TNDCRQQEFR DPFGSCVPCR QCGPGMELSK
ECGFGYGEDA KCVRCRPHRF KDDWGFQKCK LCLDCALLSR FQKVNCSATS DAVCGDCLPG
FYRKTKLVGF QDMECVPCGD PPPPYEPLCT SKVNLVKIPS TASSPRDTAL AAVICSALAT
VLLALLILCV IYCKRQFMEK KPSWSLRAHD IQYSGSELSC FDRPQLGDST CRACPQCHQD
SAHTCGPVHL IPSLCCDESC HPAWLPRSCR LHTRATLQER STGPAGDTGS PAFFGSLSQS
VCGEFSDAWP LMQNPTCCDD TSSCNSYPEL TGEDLYSLNP ASKSSVSLDS SGPQDQASGG
GILTQAHSEN FPETASFSQP ANSQTEPALS QDALATWSQR DQERSDVPNL ATHMSFQEA
//
