ID   A0A1S3WPY9_ERIEU        Unreviewed;       893 AA.
AC   A0A1S3WPY9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Armadillo repeat protein deleted in velo-cardio-facial syndrome isoform X4 {ECO:0000313|RefSeq:XP_016048357.1};
GN   Name=ARVCF {ECO:0000313|RefSeq:XP_016048357.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048357.1};
RN   [1] {ECO:0000313|RefSeq:XP_016048357.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the beta-catenin family.
CC       {ECO:0000256|ARBA:ARBA00005462}.
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DR   RefSeq; XP_016048357.1; XM_016192871.1.
DR   AlphaFoldDB; A0A1S3WPY9; -.
DR   CTD; 421; -.
DR   OrthoDB; 5473239at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR028435; Plakophilin/d_Catenin.
DR   PANTHER; PTHR10372:SF5; ARMADILLO REPEAT PROTEIN DELETED IN VELO-CARDIO-FACIAL SYNDROME; 1.
DR   PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR   Pfam; PF00514; Arm; 4.
DR   SMART; SM00185; ARM; 6.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   REPEAT          337..365
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          380..423
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          640..677
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          782..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          815..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..861
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  97388 MW;  D4F35855A91EFC89 CRC64;
     MPAELRQEQS PGSQASLVTM PEAPEVLEET ITVEEDPGTP TSHVSIVTSE DGTTRRTETK
     VTKTVKTVTT RTVRQVPVGP DGLPLLDGGP PLGSFPDGPL DRHFLLRGGG PAATLSRAYL
     SSGGSFTDGP EPRDAPSYGS LSRGLGMRPL RGGPLGPDPG NGCFTLPGRR EAFPVGPEPV
     TPAGRSQPER FQAESYGLED DTRSLAADDE GGPELESDYG TATRKRPDCG RVLRTRAYED
     VADDGGELLE DRPLYPAVTA PLAQPERGSL GSLDRVVRRS PSVNSARKEP RWRDPELPEV
     LAMLRHPVDP VKANAAAYLQ HLCFENEGIK RRVRQLRGLP LLVALLDHPR AEVRRRACGA
     LRNLSYGRDT DNKAAIRDCG GVPALVRLLR AARDNEVREL VTGTLWNLSS YEPLKMVIID
     HGLQTLTHEV IVPHSGWERE PNEDSKPRDA EWTTVFKNTS GCLRNVSSDG AEARRRLREC
     EGLVDALLHA LQSAVGRKDT DNKSVENCVC IMRNLSYHVH KEVPGADRYQ EAEPVPPAGA
     VGSQRRRRDD AGCFGGKKAK GKKDSEMDRN FDTLDLPKRT EAAKGFELLY QPEVVRLYLS
     LLTESRNFNT LEAAAGALQN LSAGNWTWAT YIRATVRKER GLPVLVELLQ SETDKVVRAV
     AIALRNLSLD RRNKDLIGSY AMAELVRNVR NAQAPARPRA RLEEDTVVAV LNTIHEIVSD
     SLDNARSLLQ ARGVPALVAL TAACQSVREA KAASHVLQTV WSYKELRGAL QRDGWTKARF
     QSTAANTKGP KGALSPGSFD DSTLPLVDKN LDGEKLGSQD VIPMEALGPD GYSTVDRRER
     KSRGSELAGE SSEKEPLKSD PSRKVPPPGP SRPAVRLVDA VGDTKPQPVD SWV
//