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Database: UniProt
Entry: A0A1S3WQ07_ERIEU
LinkDB: A0A1S3WQ07_ERIEU
Original site: A0A1S3WQ07_ERIEU 
ID   A0A1S3WQ07_ERIEU        Unreviewed;       525 AA.
AC   A0A1S3WQ07;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Parathyroid hormone/parathyroid hormone-related peptide receptor {ECO:0000256|ARBA:ARBA00020798};
DE   AltName: Full=PTH/PTHrP type I receptor {ECO:0000256|ARBA:ARBA00030334};
DE   AltName: Full=Parathyroid hormone 1 receptor {ECO:0000256|ARBA:ARBA00032662};
GN   Name=PTH1R {ECO:0000313|RefSeq:XP_016048377.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048377.1};
RN   [1] {ECO:0000313|RefSeq:XP_016048377.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|ARBA:ARBA00005314}.
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DR   RefSeq; XP_016048377.1; XM_016192891.1.
DR   AlphaFoldDB; A0A1S3WQ07; -.
DR   GeneID; 103123335; -.
DR   CTD; 5745; -.
DR   eggNOG; KOG4564; Eukaryota.
DR   InParanoid; A0A1S3WQ07; -.
DR   OrthoDB; 5397182at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004991; F:parathyroid hormone receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR002170; GPCR_2_parathyroid_rcpt.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   PANTHER; PTHR45620:SF27; PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR; 1.
DR   PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PRINTS; PR00393; PTRHORMONER.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   SUPFAM; SSF111418; Hormone receptor domain; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_016048377.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        128..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..111
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          126..399
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  58449 MW;  A42C63470D118026 CRC64;
     MEPDKGWAST ATSGKPGKDM APGDHYPGSE EDTDGPASRR GSAPCLPEWD HILCWPLGAP
     GKVVAVPCPD YIFDFNHKGH AYRRCDSNGS WELAPGHNRT WANYSECLTF MPNETRHGVR
     DVFERLGLIY TVGYSLSLAS LTVAVLILAY FRRLHCTRNY IHMHLFLSFM LRAVSIFVKD
     AVLYSGASVD EAERLTEEEL RAIVQAPPPP AAAAAGCRVT VTFFLYFLAT NYYWILVEGL
     YLHSLIFMAF FSEKKYLWSF TVFGWGVPAI FVAVWVSARA TLANTGCWDL SSGSKKWIIQ
     VPILVSIVIN FILFINIVRV LATKLRETNA GQCDTGQQYR KLLKSTLVLM PLFGVHYIVF
     MAMPYTEVSG TLWQVQMHYE MLFNSFQGFF VAIIYCFCNG EVQAEVKKSW SRWTLALDFK
     RKARSGSSSY SYGPMVSHTS VTNVGPRTSL GLPLSPRLLP AATNGHPQLP GHSKLGPPLL
     QPAPPVAARP KDEGFLNGSC SGLDEENSGP ERPAALLQEE WETVM
//
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