ID A0A1S3WQ24_ERIEU Unreviewed; 1552 AA.
AC A0A1S3WQ24;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Adhesion G protein-coupled receptor B2 isoform X2 {ECO:0000313|RefSeq:XP_016048445.1};
GN Name=ADGRB2 {ECO:0000313|RefSeq:XP_016048445.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048445.1};
RN [1] {ECO:0000313|RefSeq:XP_016048445.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_016048445.1; XM_016192959.1.
DR CTD; 576; -.
DR OrthoDB; 4181250at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016048445.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1552
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010353534"
FT TRANSMEM 923..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1063..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1111..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1141..1161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1168..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 507..577
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 919..1193
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 216..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 169355 MW; 2E7EA82C5A30D5D5 CRC64;
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP
DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLVNFTCLRP NPEEALAQVE SEVGRPEEEE
EAAGLELCGG SGPFTFLHFD KNFVQLCLSA EPSEAPRLLA PAALAFRFVE VLLINNNNSS
QFTCGVLCRW SEECGRAAGR ACGFAQPGCS CPGEAGAGPP TTTPPGPPVA HTLSNALVPG
GPAPPAEADL HSGSSNDLFT TEMRYGEEPE EEPKVKTQWP RSADEPGLYM AQTGDPAAEE
WSPWSVCSLT CGQGLQVRTR SCVSSPYGTL CSGPLRETRP CNNSATCPVH GVWEEWGSWS
LCSRSCGRGS RSRMRTCVPP QHGGKACEGP ELQTKLCSMA ACPVEGQWLE WGPWGPCSTS
CANGTQQRSR KCSVAGPAWA TCSGALTDTR ECSNLECPAT DGKWGPWNSW SLCSKTCDTG
WQRRFRMCQA TGTQGYPCEG TGEEVKPCSE KRCPAFHEMC RDEYVMLMTW KKAAAGEIIY
NKCPPNASGS ASRRCLLSAQ GVAYWGLPSF ARCISHEYRY LYLSLREHLA KGQRMLAGEG
MSQVVRSLQE LLARRTYYSG DLLFSVDILR NVTDTFKRAT YVPSADDVQR FFQVVSFMVD
AENKDKWDDA QQVSPGSVHL LRVVEDFIHL VGDALKAFQS SLIVTDNLVI SIQREPISAV
SSDITFPMRG RRGMKDWVRH SEDRLFLPKE VLSLSSPGKP TTTGTVSSPG RGRGPGTVPP
GPGYSHQRLL PADPEEASSY FVIGAVLYRT LGLILPPPRP PLAVTSRVMT VTVRPPTQPP
AEPLITVELS YIINGTTDPH CASWDYSSTD ANSGDWDMES CHTLETHAAH TRCQCQHLST
FAVLAQPPKD LTLELVGSPS VPLVIGCAVS CMALLTLLAI YAAFWRFIKS ERSIILLNFC
LSILASNILI LVGQSPVLSK GVCTMTAAFL HFFFLSSFCW VLTEAWQSYL AVIGRMRTRL
VRKRFLCLGW GLPALVVAVS VGFTRTKGYG TSSYCWLSLE GGLLYAFVGP AAVIVLVNML
IGIIVFNKLM ARDGISDKSK KQRAGSERCP WASLLLPCSA CGAVPSPLLS SASARNAMAS
LWSSCVVLPL LALTWMSAVL AMTDRRSVLF QALFAVFNSA QGFVITAVHC FLRREVQDVV
KCQMGVCRAD ESEDSPDSCK NGQLQILSDF EKDVDLACQT VLFKEVNTCN PSTITGTLSR
LSLDEDEEPK SCLVGPEGGL SFSPLPGNIL VPMASSPGLG EPPPPQEANP VYMCGEGGLR
QLDLTWLRQT EPGSEGDYMV LPRRTLSLQP GGGGGGGEDL PRARPEGTPR RAAKALTHTE
GYPSFLSVEH SSLGLGPAYG SLQNPYGMTF QPPPPTPSPH QVSEPGERSR TMPRTVPGST
MKLGSLERKK LRYSDLDFEV MHTRKRHSEL YHELNQKFHT FDRYRSQSTA KEKPSPGERP
SLSQQRRHQS WSTFKSMTLG SLPPKPRERL ALHRTPAWEP AEPPDGDFQT EV
//