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Database: UniProt
Entry: A0A1S3WQF9_ERIEU
LinkDB: A0A1S3WQF9_ERIEU
Original site: A0A1S3WQF9_ERIEU 
ID   A0A1S3WQF9_ERIEU        Unreviewed;      4889 AA.
AC   A0A1S3WQF9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 1 {ECO:0000313|RefSeq:XP_016048603.1};
GN   Name=RYR1 {ECO:0000313|RefSeq:XP_016048603.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Insectivora; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048603.1};
RN   [1] {ECO:0000313|RefSeq:XP_016048603.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   RefSeq; XP_016048603.1; XM_016193117.1.
DR   GeneID; 103123781; -.
DR   CTD; 6261; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_016048603.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4500   4523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4689   4711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4770   4793       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1358   1571       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1874   1930       {ECO:0000256|SAM:Coils}.
FT   COILED     2919   2939       {ECO:0000256|SAM:Coils}.
FT   COILED     3373   3393       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4889 AA;  551113 MW;  B010AAC15025ADB8 CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EHLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSRMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTI HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ ADASFMQTLW NMNPICSCCE EGYVTGGHVL RLFHGHMDEC LTISSSDSED
     QRRIVFYEGG AVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VVDASKAHTK ATSFCFRISK EKLDVGPKRD IEGMGPPEIK YGESLCFVQH VASGLWLTYA
     APDPKALRLG VLKKKAILHQ EGHMDDALSL TRCQQEESQA ARMIYSTAGL YNQFIKGLDS
     FSGKPRGSGP PVGTALPIEG VILSLQDLIG YFEPPSEELQ HEEKQTKLRS LRNRQSLFQE
     EGMLSLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF
     STNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGSTQYS
     KWYFEVMVDE VTPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVARLV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFES FNLDGLFFPV
     VSFSAGVKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGPRGPHLV
     GPSRCLSHMD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
     KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM
     MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIVARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQES SQVDSQSRWD RVRIFRAEKS
     YAVQSGRWYF EFEAVTTGEM RVGWARLELR PDVELGADEL AYVFNGHRGQ RWHLGSEPFG
     RPWQPGDVVG CMIDLTENNI IFTLNGEILM SDSGSETAFR DIEIGDGFLP VCSLGPGQVG
     HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEAVPL EHPHYEVARV
     DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH FRCTAGATPL APSGLQPPSE
     DEARAAEPDS DYENLRRSAG GWGEVEGGKD GTIKEGTPGS TTQAGGEAQP TRVENEKDAT
     TEKSKKRGFL FKAKKVAMMT QPPATPTLPR LPREVVPMDN RDDPEIILNT TTYYYSVRIF
     AGQEPSCVWA GWVTPDYHQH DMNFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
     VSPGQQGRIS HTDFVIGCLV DLATGLMNFT VNGKESNTFY QVEPNTKLFP AVFVLPTNQN
     VIQFELGKQK NIMPLSAAMF LSERKNSAPQ CPPRLEMQML MPVSWSRMPN HFLQVDTHRA
     GERLGWAVQC QDPLTMMALH IPEENRCMDI LELSERLDLQ RFHSHTLCLY RAVCALGNNR
     VAHALCSHVD QAQLLHALED AHLPGPLRAG FYDLLISIHL ESACRSRRSM LSEYIVPLTP
     ETCTITLFPP SKGGEEDDGP RRHGLPGVGV TTSLRPPHHF SPPCFVAALP AAGVAEAPAR
     LSPSIPLEAL RDKALRMLGE AVRDGGQQAR DPVGGSVEFQ FVPVLKLVST LLVMGVFGDE
     DVKQILKMIE PEVFKEQEEE EEEGEEEEED EEEKEEDEEE EAQEKEDEEK EEEEEEEETA
     EGEKEEGLEE GLLQMKLPES VKLQMCHLLE YFCDQELQHR VESLAAFAER YVDKLQGNQR
     GRYGLLMKAF TMSAAETARR TREFRSPPQE QINMLLHFKD GTNDEDCPLP EDLREELAKF
     HQDLLAHCGI QLEGEEEEPE EEATLGSRLK SLLEKVRLLK KKEEKPEEEP PAEESQPKSL
     QELVSHTVVR WAHEDFVQSP ELVRAMFSLL HRQYDGLGEL LRALPRAYTI SPSSMEDTMS
     LLECLGQIRS LLIVQMGPQE ENLMIQSIGN IMNNKVFYQH PNLMRALGMH ETVMEVMVNV
     LGGGESKEIR FPKMVTSCCR FLCYFCRISR QNQRSMFDHL SYLLENSGIG LGMQGSTPLD
     VAAASVIDNN ELALALQEQD LEKVVSYLAG CGLQSCPMLL AKGYPDIGWN PCGGEHYLDF
     LRFAVFVNGE SVEENANVVV RLLIRKPECF GPALRGEGGS GLLAAIEEAI RISEDPARDG
     PGVRRDRRRE HFGEEPPEEN RVHLGHAIMS FYAALIDLLG RCAPEMHLIQ AGKGEALRIR
     AILRSLVPLD DLVGIISLPL QIPTLGKDGA LVQPKMSASF VPDHKASMVL FLDRVYGIEN
     QDFLLHVLDV GFLPDMRAAA SLDTATFSTT EMALALNRYL CLAVLPLITK CAPLFAGTEH
     RAIMVDSMLH TVYRLSRGRS LTKAQRDVIE DCLMALCRYI RPSMLQHLLR RLVFDVPILN
     EFAKMPLKLL TNHYERCWKY YCLPTGWANF GVTSEEELHL SRKLFWGIFD SLAHKKYDPE
     LYRMAMPCLC AIAGALPPDY VDASYSSKAE KKATVDAEGN FDPRPVETLN VIIPEKLDTF
     INKFSEYTHE KWAFDKIQSN WSYGENIDEE LKTHPMLRPY KTFSEKDKEI YRWPIKESLK
     AMIAWEWTIE KAREGEEEKT EKKKTRKISQ NAQTYDPREG YNPQPPDLSG VTLSRELQAM
     AEQLAENYHN TWGRKKKQEL EAKGGGTHPL LVPYDTLTAK EKSRDREKAQ ELLKFLQMNG
     YAVTRGLKDM ELDTSSIEKR FAFGFLQQLL RWMDISQEFI AHLEAVVSSG RVEKSPHEQE
     IKFFAKILLP LISQYFTNHC LYFLSTPAKV LGSGGHASNK EKEMITSLFC KLAALVRHRV
     SLYGTDAPAV VNCLHILARS LDARTVMKSG PEIVKAGLRS FFESASEDIE KMVENLRLGK
     VSQARTQVKG VGQNITYTTV ALLPVLTTLF QHIAQHQFGD DVILDDVQVS CYRTLCSIYS
     LGTTKNPYVE KLRPALGECL ACLAAAMPVA FLEPELNEYN ACSVYTTKSP RERAILGLPS
     SVEEMCPDIP VLERLMADIG GLAESGARYM EMPHVIEITL PMLCSYLPRW WERGPEMPPP
     GAPPPCTAVT SSHLNSLLGN ILRIIVNNLG IDEASWMKRL AVFAQPIVSR ARPELLHTHF
     IPTIGRLRKR AGKVVAEEEQ LRLEAKAEAE EGELLVRDEF SVLCRDLYAL YPLLIRYVDN
     NRAHWLTEPN SNAEELFRMV GEIFIYWSKS HNFKREEQNF VVQNEINNMS FLTADNKSKM
     AKAGDVQSGG SDQERTKKKR RGDRYSVQTS LIVATLKKML PIGLNMCAPT DQDLITMAKI
     RYALKDTDEE VREFLQNNLH CQGKVEGSPS LRWQMALYRG LPGREDDADN PEKIVRRVQE
     VSAVLYHLEQ TEHPYKSKKA VWHKLLSKQR RRAVVACFRM TPLYNLPTHR ACNMFLESYK
     ALWILTEDHS FENRMIDDLS KAGKKKEEEE EVEEKKPDPL HQLVLHFSRT ALTEKSKLVE
     DYLYMAYADI MAKSCHLEEG GENGEGEEEE AEVSFEEKEM EKQRLLYQQA RLHNRGAAEM
     VLQMISACKG ETGAMVSSTL KLGISILNGG NADVQQKMLD YLKDKKEVGF FQSIQALMQT
     CSVLDLNAFE RQNKAEGLGM VNEDGTVINR QNGEKVMADD EFTQDLFRFL QLLCEGHNND
     FQNYLRTQTG NTNTINIIIC TVDYLLRLQE SISDFYWYYS GKDVIEEQGK RNFSKAMSVA
     KQVFNSLTEY IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MMMKLAQDSS QIELLKELLD
     LQKDMVVMLL SLLEGNVVNG MIARQMVDML VESSSNVEMI LKFFDMFLKL KDIVGSEAFQ
     DYVTDPRGLI SKKDFQKAMD SQKQFSGPEI QFLLSCSEAD ENEMINCEEF ANRFQEPARE
     IGFNVAVLLT NLSEHVPHDP RLRTFLELAE SILEYFRPYL GRIEIMGSSR RIERIYFEIS
     ETNRAQWEMP QVKESKRQFI FDVVNEGGES EKMELFVSFC EDTIFEMQIA AQISEPEGEP
     EEDDDEGGEG DEEAAAHEAG PGGADRAVAV VDGAPFRPEG PGGLGDMGDT TPVEPPTPEG
     SPIIKRKLGV DGEQEELPPE PEPEPEPEPE PEKTDAENGE KEAPEPPPEP PKKTAAPSPP
     PKKEGGSAGL EFWNELEVQR VKFLNYLSRN FYTLRFLALF LAFAINFILL FYKVSDSPPG
     EDDTEGSAAG DLSGAGSGSG SGWGSGAGEE AEGDEDENMV YYFLEESTGY MEPALRCLSL
     LHTLVAFLCI IGYNCLKVPL VIFKREKELA RKLEFDGLYI TEQPEDDDVK GQWDRLVLNT
     PSFPSNYWDK FVKRKVLDKH GDIFGRERIA ELLGMDLSSL EITAHNERKP APPPGLLTWL
     MSIDIKYQIW KFGVIFTDNS FLYLSWYMVM SLLGHYNNFF FAAHLLDIAM GVKTLRTILS
     SVTHNGKQLL MTVGLLAVVV YLYTVVAFNF FRKFYNKSED EDEPDMKCDD MMTCYLFHMY
     VGVRAGGGIG DEIEDPAGDE YELYRVVFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE
     QVKEDMETKC FICGIGSDYF DTTPHGFDTH TLEEHNLANY MFFLMYLINK DETEHTGQES
     YVWKMYQERC WDFFPAGDCF RKQYEDQLS
//
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