ID A0A1S3WRB5_ERIEU Unreviewed; 6600 AA.
AC A0A1S3WRB5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Obscurin {ECO:0000313|RefSeq:XP_016048913.1};
GN Name=OBSCN {ECO:0000313|RefSeq:XP_016048913.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048913.1};
RN [1] {ECO:0000313|RefSeq:XP_016048913.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR RefSeq; XP_016048913.1; XM_016193427.1.
DR STRING; 9365.ENSEEUP00000011877; -.
DR CTD; 84033; -.
DR InParanoid; A0A1S3WRB5; -.
DR OrthoDB; 4633043at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 7.
DR CDD; cd20971; IgI_1_Titin-A168_like; 1.
DR CDD; cd13239; PH_Obscurin; 1.
DR CDD; cd12025; SH3_Obscurin_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 58.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR035526; Obscurin_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR35971:SF4; OBSCURIN; 1.
DR PANTHER; PTHR35971; SI:DKEY-31G6.6; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 49.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 54.
DR SMART; SM00408; IGc2; 46.
DR SMART; SM00406; IGv; 13.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 54.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 45.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..200
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 236..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 515..610
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 702..785
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 807..875
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 881..959
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 973..1051
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1065..1143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1157..1235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1249..1327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1341..1427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1433..1511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1525..1603
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1617..1695
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1709..1803
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1818..1889
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1891..1977
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1982..2066
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2160..2244
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2284..2375
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2463..2547
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2641..2725
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2821..2905
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2911..2994
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3090..3164
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3179..3263
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3268..3351
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3356..3439
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3444..3515
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3532..3615
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3620..3703
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3708..3791
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3796..3879
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3883..3968
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3973..4057
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4063..4155
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4243..4332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4520..4614
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4617..4704
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4890..4981
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5116..5205
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5250..5339
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5361..5457
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5593..5660
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 5686..5869
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 5887..5996
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 6006..6089
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6100..6190
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 4817..4861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5547..5590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6230..6290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5828..5855
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5567..5583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6253..6267
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6600 AA; 719519 MW; 20346FFD683A0541 CRC64;
MDHSSFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDRQPV EAGARFRLAQ
DGDLYRLTIL DLALGDSGQY VCRARNTIGE AFAAVGLQVN SEAAVAEQAP HFLLRPTSIR
VREGAEATFR CRVRGSPPMA VSWAKDGRRL GEPDASRVQV EASGEASALR IQAARPRDGG
TYTVRAENPL GAASADASLT VDADADTAGP PGASTAALLE HLQRRREAMR AADGAPPSPP
CTGTRTCTVT EGKHARLSCY VTGEPKPETV WKKDGQLVAE GRRHVVYEDA QENFVLKILF
CKQSDRGLYT CTASNLVGQT YSSVLLVVRE PAVPFTKRLQ DLEVREKESA TFRCEVAQPA
TQAAWFKEET RLWASAKYGI EEAGTERRLT VHNISADDDA VYICETTEGS RTVAELSVQG
NLTRKLPRKT AVRVGDTAMF CVELAKPEGP VHWLRNQEEV VAGGRVAITS EGMCHTLTIA
QCSLEDVGEV AFVAGDCRTS TRFCVSAPRK PPLHAPEGPV VKSRTEGSVT LAWSPPPRGV
TIDGYLVEKR RLGAYAWSRC HEMEWVATTE LTVSGVTQEG DFQFRVSAVN SFGQSPYVEF
PGTIHLTPQL AVKTPLKAME IVEGGEVTFS VDLSLVSVGE WFLDGRALKS SSMYVIQCDG
TRHALTIRRV PASLHGAELK FMANGIESSI KMEVRAAPGL SPKHPTAARE VLARLHEEAE
LLAELSDQAA AVTWLKDGRA LPPGPKYEVQ AVAGRRVLLV RDVVRDDAGL YECISRGDHL
AYQLSVQGLT SFLHKDTTGS YVDAVAGGPA RFECQTSEAQ MRVRWYKDGK EIARSSQHFT
QEDEGTWHRL VATSVTRQDQ GTYSCRAGED SIDFQLRVQV PKVVFAKEQQ ARSEVQAEAG
ASATLSCEVA QTQTEVTWYK DGKKLSSSSR VRVEAQGCSR RLVVQQAGKA DAGEYSCEAG
GQKVSFHLDV KEPKVVFAKE QQARSEVRAE AGASATLNCQ VSQAQTEVTW YKDGKKLSSS
SRVRVEAQGC SRRLVVQQAG KADAGEYSCE AGGQKVSFHL DVKEPKVVFA KEQQAHSEVR
AEAGASATLS CEVAQTQTEV TWYKDGKKLS SSSRVRVEAQ GCSRRLVVQQ AGKADAGEYS
CEAGGQKVSF HLDVKEPKVV FAKEQQARSE VQAEAGASAT LNCQVAQAQT EVTWYKDGKK
LTSSSKVRVE AQGCSRRLVV QQAGKADAGE YSCEAGGQKV SFCLDVKEPK VVFAKEQQAS
SEVQAEAGAS VTLRCEVAQA QTEVTWYKDG KKLSSSSKVR VEAQGCSRRL VVQQAGKADA
GEYSCEAGGQ KVSFHLDVKE PKMVFAKEQQ AHSEVQAEVG ASAILSCEVA QTQTEVTWYK
DGKKLTSSSR VRVEAQGCSR RLVVQQAGKA DAGEYSCEAG GQKISFNLDV KEPKVVFAKE
QQAHSEVQAE AGASATLSCE VAQAQTEVTW YKDGKKLSSS SKVRVEAQGC SRRLVVQQAG
KADAGEYSCE VGGQKVSFCL DVKEAKVVFA KEQQASSEVQ SEAGASATLS CEVAQTQTEV
TWYKDGKKLS SSSKVRVEAH GCSRRLVVQQ AGKADAGEYS CEAGGQKVSF CLDVKEPKVV
FAKEQQARSE VQAEAGASAT LSCEVAQAQT EVTWYKDGKK LSSSSKVRVE AQGCSRRLVV
QQAGKADAGE YSCEAGGQKV SFCLDVTAPE SPALERPGRR EPLVVKEHED IVLTATVATS
SPAAVTWLKD GMEIRRSKRH ETASRGNKHT LTVHGAQTLD SAIYSCRVGE QGQDFPVQVE
EVAAKFSQPL APVSGELGGT VTLACELSPA QAEVVWRCGS MQLRPGKRFQ MVADGPRRLL
TVSGLRAEDA GEYVCESRED RTSAQLTVSV PREVKFTSGL SAVTAEEGCE ATFQCVVSPS
DVVVTWFRDG TQLQPSGKFV MSQSGSSHSL TISDLTLEDA GQISVDVEGV KSVAALRVRE
APVLFKKKLE PQTVEELSSV TMEVELTRPW PEVKWTRNAA ILSSGGNVEI QAENVSHRLI
LHSVGFTDRG FYGCETPHDK TQAKLSVEMR QVRLVRGLQE VEAQEQGTAT MEVELSHVDV
EGSWIKDGLR LQPGPTCHLA VRGTTHTLTL SGLQPKDAGL VGFKAEGVHT SARLVVTELP
VRFSRPLQDV MVTEKDKMTL ECELSRPNVD VRWLKDGVEL RAGKKVGIMA QGACRSLVIY
RCELGDQGVY VCDAHDAQSS ASVKVQGRTY TLIYRRVLAE DAGEIKFVAE NAESQAQLRV
KELPVTILRP LRDKIAMEKH RGVLECQVSR ASAQVRWFKG GMELRPGLRY EMVSNGLYRK
LVIIDVQPED EDTYTCDAGD VKTSAQFFVE EQSITIMRGL QDMTVMEPAP AWFECETSIP
SVRPPKWLLG KTVLQAGANV VVEQEGTVHR LKLRRTCSTM TGPVHFTIGK SRSTARLVVS
DIPVVLTRPL EPKVGREQQS VVLSCDFKPP PKAVQWYKGD MPLAPSEKYK MNLEGHMAEL
RVLRLTSADA GIYRCQAGSA QSSAEVTVEA REVSVTQPLQ DVEATEEGRA CFSCELSHED
EEVEWLLNGT PLYNDSFHEI SHQGHRHTLV LKRVRQADAG ILQVSSPKIT ASARLQVKEK
PVVFLKALDD VSAEEQGTLA LQCEVSNREA RVLWRKDGVE LGPSDKYDFL HSAATRGLVV
HDLNKDDAGI YTCHVGAEQT QARVSVHDLH VGITKRLKTT EVVEGQSCSF ECVLSHENTS
DTAVWTIGGK MVGSSGRFQA TRQGRKYMLT IQDAVPSDAG EVVFSVRDLT SKASLTVRER
PVDFSKPLED QQVARGEDVT LSCELSQSGA LVRWLRDGKA IRRSRKYEVL TEGTRAVLII
RAASIKDSGE YTCETEASKS TAHLRVEEKA NRFTEELADL QLEEKGTAVF QCKTEHPTAT
VIWRKGLLEL RASGKYSISQ EGLTLKLTIS ALEKVDSDTY TCDIGQARSQ ARLLVQGQKV
LISEDLEDVE VQEGSSATFC CRISPSDYGP VHWFLDKTPL HTNELNEIEA RPGGYHMLTL
RQLTLKDSGT VHFEAGDQRA SANLQVTEKP SIFSRELMDV TVTEGEELTL VCETTAPDSS
VSWTKDGKTL RSSVRCRLSH EGSRVQLVIT GATLQDGGRY KCHVGGSWSS SIVRVHARPV
HFREGLKDLE VQEGGAATLR CVLSSVAAPV EWRRGDEVLR AGGKYSLRQE GAVLELVVRD
LRPLDSGQYS CCFGDQVTLA TLTVKAQPAE FIGRLRSKEA TEGTTATLRC ELTKEAPVEW
RKGSETLTTK ERVILRQDGA VCELQISGLT LEDAGEYTCV CGQERTSATL TIRALPAKFT
KSLRKKESTE GSTATLCCEL SKEAPVEWKK GSETLRAGDR VSLRQAGAMC ELQIHGLTME
DAGEYLCVCG QERTSAMLTV KALPAKFTKA LRKEEATEGA IAMLYCELSK EAPVEWKKGS
ETLRTGDRVS LRQDGAMCEL QICSLAVEDA GEYSCLCGQE RTLATLAVKA QPATFKQELK
TMEATEGATA MLCCELSKVA PVEWKKGSEI LKAGDRISLK HDGTMCELQI HDLAMEDAGE
YSCVCGQERT SATLTIRALP AIFTKGLKKE EAIEGATATL RCELSKEALV EWRKGSETLS
AGDRVSLQCD GGMCELQIRG LAMEDAGEYS CICGQERTSA MLTVRALPAK FIKGLRKEEA
TEGSMATLHC ELSKETPVEW KKGSEILKTK DRVSLRQDGV LCELQIHDLA MEDAGEYSCV
CGQEKTLATL TVKALPAKFT KGLKNEEATE GSMVTLHCEL SKEAPVEWIK GSETLTTSDR
VSLRQAGAVC ELQTHGLAME DAGKYSCVCG QERTSATLTI RAPQVGFREP LQSIQAEEGT
SAYLRCELWE PSATVVWSKG GLELQADERL EPRRRGTTAE LVLRELRRED SGEYSCACGT
QTTSATLSIT AAPVRFLREL QAQEVDEGGI ARLHCELSRE GASVEWRKGS LQLFPCAKYQ
MVQEGTLAEL LVHDVELEDA GHYTCDTGHT QSTAVLSVQV PRPKFKTELQ SAEQEAGGVA
RLQCQLSDSE PGAPVQWLKE GVELHSGPKY EIRRQGATCE LLVHRLEAKD TGEYACMVGS
QKTLASIKVK EAEVTIVRGL VDAEVQADGD VEFSCEVSRA GARGVQWRLQ GLPLQNNEVT
EVTMQGDCTH ILRLKGVTPE DTGTVSFHVG IHSSSAQLTV QVPEVIILEP LKDLQLGEGQ
DAHFQCRLSR TVGQEARWAL GGVPLQANEM NDITVEQGVL HSLTLHKVTL EDAGTVSFQV
GSCSSQAQLK ITAKNKVVRG LENVEAPEGG EALFECQLAQ PEVAVHTWLL DDEPVRTSDR
AEVVYFEDGR RHLLLLKNLQ PQDSCQVTFL AGDLVTSAFL TVRGWRLEVL EPPQDVSVHV
GAQARFSCML SEVVPVGEAT WYINGAAVQP DNTDWKVTAD GNHHGLLLHS AQLHHSGEVT
FAARDAVVTA QLSVMGLPDP PEDAEVVGRS DRSVTLSWAA PMSDGGGGLC GYRVEMKAAA
TGEWQLCHEL VPGPECVVDD LAPGETYRFR VAAVSPVGAG EPVHLPQMVK LAEPLEPKPT
PQAPETRQVV VGEDLCLECE VTEAGEVIWL KGTERVQPSG RFQVLCEGRR QTLVIRGFTA
EDQGEYRCSP TQGPAPAAFQ VVLSPESGLE APLQPSLPPE AAQEGDLHLL WEALARKRRM
SREPTLDSIS ELPEEDGRLQ RLRHEAEDAA PDFSEGYSTA DELARTGEAD LSHTSSDDES
RAGTPALVTY LKKAGKPGVS PLASEAGPPA APSVKPQKQP VQPAAVSPSP LGELSAEDLG
DPSMDKAAMK IQAAFKGYKV RKEIKQQEGP VFCRTFGDTE AQVGDVLCLE CVVSSKVDVR
ACWLKDGMEL TDSRHHHIDQ LADGTCSLLV TGLGREDAGR YTCQVRSKFG QVSHSAQVAV
SGTESEAESS SGGERDDTFH RAARRLHRLF RTKGPAEVSD EEIFLSADEG PAEPEGPSNW
STYREDEHSV CIHFEALAEA QQAAARFQEM FGTLGIQVET RLSEQGPRGV EVHIGKVALA
QGAPPAPSPL STEAAPVFLT ELKNQEVLDG YPVSFDCVVT GQPVPSVRWF KDGRVLEEDD
HYMISDDQQG GHQLIITAVV PADMGVYRCL AENSVGVSST KAELRVDLTS TDYDTAADAT
ETSSYFSAQG YLSSREQEGT ESTSEEGQLP QVVEELKDLE VAPGTLLAKF QLKVKGYPVP
RLYWFKDGQP LTASEHIRMT DRKTLHSLEV LSVTREDAGQ YSAYISNSVG AAYSSARLLV
RGPNDPEDRL AADVQQHLVP PRILERFTSK KVKKGSSITF SVKVEGCPAP TVHWLREEAG
RGVLWIGRDT PGYTVASSAQ QHSLVLLDVG PQHRGTYTCI ATNAAGQALC SASLHISGLP
KEAVAAEEQG EVKAALISSF LQGAQAVSAQ MVVGSAGLAD LAVQRKEAPT MEETRGHLSL
AEVGTEEFLQ RLTSQITEMV SAKITQAKLQ VPGGDSDEES KTPSASPRHG RSRPSSSIQE
SSSESEDGDS RGEIFDIYVV TADYLPLGAE PDAITLREGQ YVEVLDSAHP LRWLVRTKPT
KSSPSRQGWV SPAYLDRRLK LSPEWGPTEA PEFPREAVSE DEYKTRLSST IKELLSSEQA
FVDKLQFLES HHMQHLDHSA HVPSAVASQR DVIFRNVKDI SHFHSSFLQE LQGCDTDDDV
AMCFIKNQAA FEKYLEFLVG RVQAESVVVS TAVQEFYKKY TEEVLSADPS QPPPPPLQHF
LEQPVERVQQ YQALLKELIR NKARNRQACA MLEQAYAVVS ALPRRAEDRL HVSLMENYPG
TLEALGEPIR QGHFIVWEGA PGARMPWKGH HRHVFLFRNH LVVCKPKRDS RTDTFSYVFR
NMMKLSSIDL NEQVEGDDRA FEVWHEREDS VRKYLLQART ATTKNSWVKE IRGIQQRLAL
PIWRAPDFEE ELADCTAELG ETVKLACRVT GTPTPVVSWY KDGKPVEVDP HHIFIEDPDG
SCALILDNLT GADSGQYMCF AASAAGNAST LGKILVQVPP YFVNKVRALP FVEGEDAQVT
CSFEGAPYPQ IRWYKDGSLL TPGGKYRTLS EPRSGVLVLE IRAACAEDLG HYECELVNRL
GSTRGGAELY MQSAALRAQE QRRREQVAAI EVTEQETRVP KKTVIIEETI TTVVKSPRGR
RPSPSKSPAR SPSRLPASPP RPGPLGSEPR YPQGAGQPCR PEAEPGRRPP VPMLYITEAE
ARTPAQPRGT GPHPKWVEVE ETIEVRVKKA GLGSTAPAGE VPGSPTGLLF TLPGGTSGGD
PNTNNSNNKL LAQEPRAGDR AKVTTDEPLV FHVDVGPEQP PEPSPAWTAE EETLLEEEEE
PQDAEGLWGR DPKILTHNGR AMTLADLDDY VPQAGETFGC LRPGHGPSND PPCEVAVLQR
EIREPTVGQP VLLNVGHPAG FFGHSARPQG ASPSGPQVRG PVGVSFSVRE ARVGATAAWK
PSFCTHIQRS MDSGQSSFKT EVSTQTLGFG TLGETVTLHI HPDEDGEQAA EPQGRTVPIR
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