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Database: UniProt
Entry: A0A1S3WRB8_ERIEU
LinkDB: A0A1S3WRB8_ERIEU
Original site: A0A1S3WRB8_ERIEU 
ID   A0A1S3WRB8_ERIEU        Unreviewed;       832 AA.
AC   A0A1S3WRB8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|RefSeq:XP_016048880.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048880.1};
RN   [1] {ECO:0000313|RefSeq:XP_016048880.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00029431}. Cytoplasmic vesicle, secretory
CC       vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004644};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004644}. Melanosome
CC       {ECO:0000256|ARBA:ARBA00004223}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_016048880.1; XM_016193394.1.
DR   AlphaFoldDB; A0A1S3WRB8; -.
DR   GeneID; 103124285; -.
DR   CTD; 535; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF68; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A1; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        401..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        542..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        569..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        634..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        765..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   832 AA;  95855 MW;  DACB6035840CD896 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
     NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLDPSEI GRGTPLRLGF VAGVINRERI
     PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
     RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
     PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDF GHGILMTLFA
     MWMVLRESRI LSQKNENEMF STVFSGRYII LLMGIFSIYT GLIYNDCFSK SLNIFGSSWS
     VRPMFTLSNW TEETLRDHSV LQLDPAISGV FGGPYPFGID PIWNIATNKL TFLNSFKMKM
     SVILGIFHML FGVSLSLFNH IYFKKPLNIY FGFIPEVIFM CSLFGYLVIL IFYKWTAYDV
     HTSKKAPSLL IHFINMFLFF YGDSEDAMLY SGQKGLQCFL VVVAMLCVPW MLLLKPLILR
     HQYLRRKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEFDFGD TMVHQAIHTI
     EYCLGCISNT ASYLRLWALS LAHAQLSEVL WTMVIHIGLK VKSLAGGLAL FFIFAAFATL
     TVAILLIMEG LSAFLHALRL HWVEFQNKFY SGNGFKFLPF SFEHIRDGKF DE
//
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