ID A0A1S3WRR5_ERIEU Unreviewed; 1418 AA.
AC A0A1S3WRR5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=FH1/FH2 domain-containing protein 3 isoform X2 {ECO:0000313|RefSeq:XP_016049056.1};
GN Name=FHOD3 {ECO:0000313|RefSeq:XP_016049056.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016049056.1};
RN [1] {ECO:0000313|RefSeq:XP_016049056.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016049056.1; XM_016193570.1.
DR GeneID; 103124674; -.
DR CTD; 80206; -.
DR OrthoDB; 2918313at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR041387; FHOD1_GBD_N.
DR InterPro; IPR014768; GBD/FH3_dom.
DR PANTHER; PTHR45920:SF3; FH1_FH2 DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF18382; Formin_GBD_N; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 18..411
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 879..1275
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1355..1387
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 326..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1369..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..842
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 158297 MW; 9CB685E2EF613F7B CRC64;
MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL RAPHKLDDCA
LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG
RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD
GMNGVINHSE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY ADSNAPLLIQ AVSAVDTKRG
VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD SFYDVVDCLE ELGIAAVSQR
HLNKKGTDLD LVEQLNIYEL ALRLEDGDET AEPPPSGRRD RRRASVCSSG VGEHQGLDRR
RSRRHSVQNI KSPLSAPTSP CSQSAPSFKT SQVRDLCEKY SNCGNSSYPS SRSSSSSVST
APTSSVSAPQ EARTEKTPPS NLLTSSFKQH QESLAAERER RRQEREERLQ RIEREERNKF
KYKYLEQLAA EAQEKELRSR SASRGRADLS LDLTSSAVPA SSASLSRSPS SPDSQETLRV
SSSSPGASEH LQVSAEDPEP EAETEQEPEA EVGKVVHEAS QELALAHAGT ESEVARVPEQ
ESEERASLSE KERQNEELNE RDNCSASSIS SSSSTLEREE KEDKLSRDRG TGVWLAGAQD
AGVNEQCGDI LTNKRFMLDM LYAHNRKPTD DEEEGDEASR PEQGAEAVAS LASRISTLQA
NSLPQDESVR RIDVGCLDNR GSVKAFAEKF NNGDLGRGSP EAEPDDKVPE KASSTPQKTE
SDHIWDQLMA NPRELRIQDM DFTDLGEEDD IDVLDVDLGH REASGPPPPP PPIFLGLPPP
PPPPLLDSVP PPPVPGNLLA PPPVFSSPQG VGWPQVPRGH PAFTKKKKTI RLFWNEVRPF
EWPCKNNRRC REFLWSKLEP IKVDTSRLEH LFESKSKELS VSKKTAADGK RQEIIVLDSK
RSNAINIGLT VLPPPRTIKI AILNFDEYAL NKEGIEKILT MIPTEEEKQK IQEAQLANPD
IPLGSAEQFL LMLSSISELS ARLHLWAFKM DYETTEKEVA EPLLDLKEGI DQLENNKTLG
FILSTLLAIG NFLNGTNAKA FELSYLEKVP EVKDTVHKQS LLHHMCTMVV ENFPDSSDLY
SEIGAVTRSA KVDFDQLQDN LCQMERRCKA SWDHLKAIAK HEMKPVLKQR MSEFLKDCAE
RIIILKIVHR RIINRFHAFL LFMGHPPYAI REVNINKFCR VISEFALEYR TTRERVLQQK
QKRANHRERN KTRGKMITDT GKFSGGSPVP PSQPQGLSYA EDAAEHENMK AVLKTSSPAV
EDATPVLGVR TRSRASRGST SSWTMGADDS PNITDDAADE IMDRIVKSAT QVPSQRVVPR
ERKRSRANRK SLRRTLKSGL TPEEARALGL VGTSELQL
//
