ID   A0A1S3WS03_ERIEU        Unreviewed;       766 AA.
AC   A0A1S3WS03;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Sorting nexin-14 isoform X8 {ECO:0000313|RefSeq:XP_016049067.1};
GN   Name=SNX14 {ECO:0000313|RefSeq:XP_016049067.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016049067.1};
RN   [1] {ECO:0000313|RefSeq:XP_016049067.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   RefSeq; XP_016049067.1; XM_016193581.1.
DR   AlphaFoldDB; A0A1S3WS03; -.
DR   CTD; 57231; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          1..124
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          156..288
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          390..510
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   766 AA;  89037 MW;  A3DB32B13B524928 CRC64;
     MVQVDIPSII TKKLLKAAMK HIEVIVKARL KVKNAEFLQQ AALEEYGPEL HVALRSRRDE
     LHYLRKLTEL LFPYILPPKA TDCRSLTLLL REILSGSVFL PSLDFLADPD TVNHLLIIFI
     DDSPPEKATE PPSPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKHEGAV
     HVLQICLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIK
     KIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
     FNRGSLSLDD FRSTQKRGES FGISRIGSKI KGVFKSTTME GAMLPNYGLT EGEDDFIEEG
     IVVMEDDSPV EAVSTPTTPR NLAAWKISIP YVDFFEDPSS ERKEKKERIP VFCIDVERND
     RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGTFPDAQLP SKRIIGPKNY EFLKSKREEF
     QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKILPDV NLGKIIKSVP GKLMKEKGQH
     LEPFIMNFIN SCESPKPKPS KPELTILSPT SENNKKLFND LFKNNANRAE NTERKQNQNY
     FMEVMTVEGV YDYLMYLGRV VFQVPDWLHH LLMGARILFK NTLEMYTDYT LQHKLEQLFQ
     EHRLVSLITL LRDAVFCENT EPRSFQDKQK RAKQTFEAMM DYIPDLIVKC IGEEAKYEGI
     RLLFDGLQQP VLNKQLTYVL LDIVVQELFP ELNKVQKEVT SVTSWM
//