ID A0A1S3WSH2_ERIEU Unreviewed; 936 AA.
AC A0A1S3WSH2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Liprin-alpha-3 {ECO:0000313|RefSeq:XP_016049318.1};
GN Name=PPFIA3 {ECO:0000313|RefSeq:XP_016049318.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016049318.1};
RN [1] {ECO:0000313|RefSeq:XP_016049318.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR RefSeq; XP_016049318.1; XM_016193832.1.
DR AlphaFoldDB; A0A1S3WSH2; -.
DR CTD; 8541; -.
DR eggNOG; KOG0249; Eukaryota.
DR InParanoid; A0A1S3WSH2; -.
DR OrthoDB; 2906732at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF4; LIPRIN-ALPHA-3; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 580..646
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 702..759
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 783..852
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 204..238
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 104093 MW; CA6D02B48DF428BB CRC64;
MSQLEEELGT AHRELGKAEE ANSKLQRDLK EALAQREDME ERITTLEKRY LSAQREATSL
HDANDKLENE LASKESLYRQ SEEKSRQLAE WLDDAKQKLQ QTLQKAETLP EIEAQLAQRV
AALNKAEERH GNFEERLRQL EAQLEEKNQE LQRARQREKM NDDHNKRLSE TVDKLLSESN
ERLQLHLKER MGALEEKNSL SEEIANMKKI QDELLLNKEQ LLAEMERMQM EIDQLRGRPP
PSYSRSLPGS ALELRYSQAP TLPSGAHLDP YGGGSGRTGK RGRWSGVKDE SSKDWDRAAP
AGSIPPPFPG ELDGSDEEEA EGMFGAELLS PSGQADVQTL AIMLQEQLEA INKEIKLIQE
EKETTEQRAE ELESRVSGSG LDSLGRYRSS CSLPPSLTTS TLASPSPPSS GHSTPRLAPP
SPAREGTDKA NHVPKEEVGV PRGEGPAIPG DTPPPTPRSA RLERMTQALA LQAGSLDDGG
PTRGSEGTPD SLHKAPKKKS IKSSIGRLFG KKEKGRMGPP GRESSSLGKE AGALPSPQPL
SFLPPSLPQL AGSQVVEQRD KRTHELLEEA CRQGLPFAAW DGPTVVSWLE LWVGMPAWYV
AACRANVKSG AIMANLSDTE IQREIGISNP LHRLKLRLAI QEMVSLTSPS APASSRTSTG
NVWMTHEEME SLTATTKPET KEISWEQILA YGDMNHEWVG NDWLPSLGLP QYRSYFMESL
VDARMLDHLN KKELRGQLKM VDSFHRVSLH YGIMCLKRLN YDRKDLERRR EESQSQIRDV
MVWSNERVMG WVSGLGLKEF ATNLTESGVH GALLALDETF DYSDLALLLQ IPTQNAQARQ
LLEKEFSNLI SLGTDRRLDE DSAKSFSRSP SWRKMFREKD LRGVTPDSAE MLPPNFRSAA
AGALGSPGLP LRKLQPEGQT SGSSRADGVS VRTYSC
//
