ID A0A1S3WT31_ERIEU Unreviewed; 3871 AA.
AC A0A1S3WT31;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Transformation/transcription domain-associated protein isoform X7 {ECO:0000313|RefSeq:XP_016049442.1};
GN Name=TRRAP {ECO:0000313|RefSeq:XP_016049442.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016049442.1};
RN [1] {ECO:0000313|RefSeq:XP_016049442.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR RefSeq; XP_016049442.1; XM_016193956.1.
DR CTD; 8295; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 2704..3287
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3512..3835
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3839..3871
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 489..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2555..2590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..523
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2041..2063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3871 AA; 438956 MW; F6A1602967499082 CRC64;
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI PTNEHLRPHT KNVLSVMFRF
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQVIP
ENTVPPPEMV GMITTIAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK
LNIHNVVAEF VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL
IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC
KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAV
EASLPGVPTA PAAPGPAPSP APVPTPAPAP PPPPTPATPV TPAPVPSFEK QGEKDKEDKQ
TFQVTDCRSL VKTLVCGVKT ITWGITSCKA PGEAQFIPNK QLQPKETQIY IKLVKYAMQA
LDIYQVQIAG NGQTYIRVAN CQTVRMKEEK EVLEHFAGVF TMMNPLTFKE IFQTTVPYMV
ERISKNYALQ IVANSFLANP TTSALFATIL VEYLLDRLPE MGSNVELSNL YLKLFKLVFG
SVSLFAAENE QMLKPHLHKI VNSSMELAQT AKEPYNYFLL LRALFRSIGG GSHDLLYQEF
LPLLPNLLQG LNMLQSGLHK QHMKDLFVEL CLTVPVRLSS LLPYLPMLMD PLVSALNGSQ
TLVSQGLRTL ELCVDNLQPD FLYDHIQPVR AELMQALWRT LRNPADSISH VAYRVLGKFG
GSNRKMLKES QKLHYVVTEV QGPSITVEFS DCKASLQLPM EKAIETALDC LKSANTEPYY
RRQAWEVIKC FLVAMMSLED NKHALYQLLA HPNFTEKAIP SVIISHRYKA QDTPARKTFE
QALTGAFMSA VIKDLRPSAL PFVASLIRHY TMVAVAQQCG PFLLPCYQVG SQPSTAMFHS
EENGSKGMDP LVLIDAIAIC MAYEEKELCK IGEVALAVIF DVASIILGSK ERACQLPLFS
YIVERLCACC YEQAWYAKLG GVVSIKFLME RLPLTWVLQN QQTFLKALLF VMMDLTGEVS
NGAVAMAKTT LEQLLMRCAA PLKDEERAED IVAAQEKSFH HVTHDLVREV TSPNSTVRKQ
AMHSLQVLAQ VTGKSVTVIM EPHKEVLQDM VPPKKHLLRH QPANAQIGLM EGNTFCTTLQ
PRLFTMDLNV VEHKVFYTEL LNLCEAEDSA LTKLPCYKSL PSLVPLRIAA LNALAACNYL
PQSREKIIAA LFKALNSTNS ELQEAGEACM RKFLEGATIE VDQIHTHMRP LLMMLGDYRS
LTLNVVNRLT SVTRLFPNSF NDKFCDQMMQ HLRKWMEVVV LTHKGGQRSD GNESMSECGR
CSLSPFCQFE PAMDEVEEMK ICSAIINLFH LIPAAPQTLV KPLLEVVMKT ERAMLIEFPP
RVFQAGSPFR EPLIKFLTRH PSQTVELFMM EATLNDPQWS RMFMSFLKHR DARPLRDVLA
ANPNRFITLL LPGGTQPAVR PGSPSTMRLD LQFQAIKIIS IIVKNDDSWL ANQHSLVSQL
RRVWVSETFQ ERHRKENMAA TNWKEPKLLA YCLLNYCKRN YGDIELLFQL LRAFTGRFLC
NMAFLKEYME EEIPRNYSIT QKRALFFRFV DFNDPNFGDE LKAKVLQHIL NPAFLYSFEK
GEGEQLLGPP NPEGDNPESI TSVFISKVLD PEKQADMLDS LRIYLLQYAT LLVEHAPHHI
HDNNKNRNSK LRRLMTFAWP CLLSKACVDP ACKYSGHLLL AHIIAKFAIH KKIVLQVFHS
LLKAHAMEAR AIVRQAMAIL TPAVPARMED GHQMLTHWTR KIIVEEGHTV PQLVHILHLI
VQHFKVYYPV RHHLVQHMVS AMQRLGFTPS VTIEQRRLAV DLSEVVIKWE LQRLKDQQPD
SDMDTSSSGE GSSMSSSIKR GLSVDSAQEV KRFRTATGAI SAVFGRSQSL PGPDSLLTKP
IDKQHMDTVV NFLIRVACQV NDNTNTAGSP GEVLSRRCVT LLKTALRPDM WPKSELKLQW
FDKLLMSVEQ PSQVNYGNIC TGLEVLSFLL TVLQAPAILS SFKPLQRGIA ACMTCGNTKV
LRAVHSLLSR LMSIFPTEPS TSSVASKHEE LECLYAAVGK VIYEGLTNYE KATSANPSQL
FGTLMILKSA CSNNPSYIDR LISVFMRSLQ KMVREHLNPQ AASGSAEATS GTSELVMLSL
ELVKTRLAVM SMEMRKNFIQ AILTSLIEKS PDSKILRAVV KIVEEWVKNN SPMAVNQTPT
LREKSILLVK MMTYIEKRFP EDLELNAQFL DLVNYVYRDE TLSGSELTAK LEPAFLSGLR
CAQPLIRAKF FEVFDNSMKR RVYERLLYVT CSQNWEAMGN HFWIKQCIEL LLAVCEKSTP
IGTSCQGAML PSITNVINLA DSHDRAAFAM VTHVKQEPRE RENSESKEED VEIDIELAPG
DQTSTPKTKE LSEKDIGNQL HMLTNRHDKF LDTLREVKTG ALLSAFVQLC HISTTLAEKT
WVQLFPRLWK ILSDRQQHAL AGEISPFLCS GSHQVQRDCQ PSALNCFVEA MSQCVPPIPI
RPCVLKYLGK THNLWFRSTL MLEHQAFEKG LSLQIKPKQT TEFYEQESIT PPQQEILDSL
AELYSLLQEE DMWAGLWQKR CKYSETATAI AYEQHGFFEQ AQESYEKAMD KAKKEHERSN
ASPAIFPEYQ LWEDHWIRCS KELNQWEALT EYGQSKGHIN PYLVLECAWR VSNWTAMKEA
LVQVEVSCPK EMAWKVNMYR GYLAICHPEE QQLSFIERLV EMASSLAIRE WRRLPHVVSH
VHTPLLQAAQ QIIELQEAAQ INAGLQPTNL GRNNSLHDMK TVVKTWRNRL PIVSDDLSHW
SSVFMWRQHH YQGKPTWSGM HSSSIVTAYE NSSQHDPSSN NAMLGVHASA SAIIQYGKIA
RKQGLVNVAL DILSRIHTIP TVPIVDCFQK IRQQVKCYLQ LAGVMGKNEC MQGLEVIEST
NLKYFTKEMT AEFYALKGMF LAQINKSEEA NKAFSAAVQM HDVLVKAWAM WGDYLENIFV
KERQLHLGVS AITCYLHACR HQNESKSRKY LAKVLWLLSF DDDKNTLADA VDKYCIGVPP
IQWLAWIPQL LTCLVGSEGK LLLNLISQVG RVYPQAVYFP IRTLYLTLKI EQRERYKSDP
GPIRATAPMW RCSRIMHMQR ELHPTLLSSL EGIVDQMVWF RENWHEEVLR QLQQGLAKCY
SVAFEKSGAV SDAKITPHTL NFVKKLVSTF GVGLENVSNV STMFSSAASE SLARRAQATA
QDPVFQKLKG QFTTDFDFSV PGSMKLHNLI SKLKKWIKIL EAKTKQLPKF FLIEEKCRFL
SNFSAQTADV EIPGEFLMPK PTHYYIKIAR FMPRVEIVQK HNTAARRLYI RGHNGKIYPY
LVMNDACLTE SRREERVLQL LRLLNPCLEK RKETTKRHLF FTVPRVVAVS PQMRLVEDNP
SSLSLVEIYK QRCAKKGIEH DNPISRYYDR LATVQARGTQ ASHQVLRDIL KEVQSNMVPR
SMLREWALHT FPNATDYWTF RKMLTIQLAL IGFAEFVLHL NRLNPEMLQI AQDTGKLNVA
YFRFDINDAT GDLDANRPVP FRLTPNISEF LTTIGVSGPL TASMIAVARC FAQPNFKVDG
ILKTVLRDEI IAWHKKTQED TSSPLSAAGQ PENMDSQQLV SLVQKAVTAI MTRLHNLAQF
EGGESKVNTL VAAANSLDNL CRMDPAWHPW L
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