ID A0A1S3WUR5_ERIEU Unreviewed; 653 AA.
AC A0A1S3WUR5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=MARCH7 {ECO:0000313|RefSeq:XP_016049909.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016049909.1};
RN [1] {ECO:0000313|RefSeq:XP_016049909.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_016049909.1; XM_016194423.1.
DR AlphaFoldDB; A0A1S3WUR5; -.
DR CTD; 64844; -.
DR OrthoDB; 1342875at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16812; RING_CH-C4HC3_MARCH7; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14471:SF1; E3 UBIQUITIN-PROTEIN LIGASE MARCHF7; 1.
DR PANTHER; PTHR14471; MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER; 1.
DR Pfam; PF12906; RINGv; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51292; ZF_RING_CH; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 547..617
FT /note="RING-CH-type"
FT /evidence="ECO:0000259|PROSITE:PS51292"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 72032 MW; C25CD59F5DB8914B CRC64;
MDSKPSRIPR RISVQPSTSL SARMMSGSRG SSLNDTYHSR DSSFRLDSEY QPSSVSASAS
PYQSAWYSES EITQGARSRS QNQQRDHDSK RPKLSCTNCT STSAGRNIGH GLNTISDSSW
RHSQVPRSSS VVLGAFGTDL MRERRDLERR TDSSISNVMD YGHRSGDFTA SSYVQDRAPS
YSQGARPKEN SVSALQLNAS STNPQMPSEH AIPYSRDSRR NSLRSNFSPR ELDSSPNSTQ
PGFSYISNRD ETSTIGSSVR AGSSQRSFQE SSDNDGRRTT RRLLSRIASS MSSTFFPRRS
SQDSLNTRSL SSENSYISPR ILTASQSRNN STASTSDVSD HRVSETSQGF RFLRRRWGLS
SLSQNHGSEP DSEHLNQESE SRSTGPWLSS SLRNRCTPLF SRRRREGRDE SSRIPTSDIS
SRSHHIFRRE SNEVVHLEAQ NDPHGVAANR PHASAASSSA ATGGSTSDST HNGRNTGLTG
ILPGSLFRFA VPPALGSNLT DNVMITVDII PSGWNPSDGK SDKTKIAPSR DPEKLQKIKE
SLLLEDSEEE EGDLCRICQM AAASSSNLLI EPCRCTGSLQ YVHQECMKKW LQAKINSGSS
LEAVTTCELC KQKLQLNLED FDIHELHRAH ANEQVSIFCL IWLSMSSSAL VST
//
