ID A0A1S3WVN2_ERIEU Unreviewed; 512 AA.
AC A0A1S3WVN2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=LOC103127361 {ECO:0000313|RefSeq:XP_016050347.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016050347.1};
RN [1] {ECO:0000313|RefSeq:XP_016050347.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_016050347.1; XM_016194861.1.
DR AlphaFoldDB; A0A1S3WVN2; -.
DR eggNOG; KOG3626; Eukaryota.
DR InParanoid; A0A1S3WVN2; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF89; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 95..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 255..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 376..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 410..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 30..512
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 453..511
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT NON_TER 512
FT /evidence="ECO:0000313|RefSeq:XP_016050347.1"
SQ SEQUENCE 512 AA; 56657 MW; A1DD8C4A21B9B827 CRC64;
MDLNQHLNKT AEAELSKQRK PICCNGFKMF MAALSLSFIC KALGGVIMKS SIIQIERRFE
ISSSTAGLID GSFEIGNLLV IVFVSYFGSR LHRPKIIGIG CFIMGTGTIL TALPHFFMGH
YKYSKETHIN PSVNSTSSLP TCMPNQDVLL NRTSPEIVEK GYEKESESYM WIFVLMGNML
RGIGETPIGP LGISYLDDFA EEGHSSFYLG TLNAVAMIGP IIGFVMGSLV SKMYVDIGYV
DLSTIRITPK DSRWVGAWWL SFIIAGLLAI LSSIPFFFLP KSLDKPQKER RASGSLYGLK
TKEERSQMVN VINHKQNVNE NMPGFFQSLK TILTNQLYVL ALLATLLHIS SFIGHITYIF
KYLEQQYSQS ASETNVLLGV LSLPTIAAGI FTGGYIIKRF KFTMVGIAKF SLFNVVISFI
FFLSDFLLIC ENKSVAGLTL TYDGNSPLES HINVPLSYCN SDCNCDENQW EPICGDNGIT
YISPCLAGCK SSSGTKKPIV SDLLSYLSIK IS
//
