ID A0A1S3WYL6_TOBAC Unreviewed; 1876 AA.
AC A0A1S3WYL6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Vacuolar protein sorting-associated protein 8 homolog isoform X3 {ECO:0000313|RefSeq:XP_016432737.1};
GN Name=LOC107759344 {ECO:0000313|RefSeq:XP_016432737.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016432737.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016432737.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS8 family.
CC {ECO:0000256|ARBA:ARBA00009422}.
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DR RefSeq; XP_016432737.1; XM_016577251.1.
DR GeneID; 107759344; -.
DR OMA; HEHMALR; -.
DR OrthoDB; 120292at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR025941; Vps8_central_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12816; Vps8; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 484..518
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1685..1733
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1876 AA; 209011 MW; E3A43656C831E94A CRC64;
MELDLDSFLE SHADDDDDDH LLHHRTVDEI LLNHSSSSSS SSSSSSSPSP PSSPSAAHGH
NYLDRRSRSV DSSSQSAEPR PESISSKQSS EFFSPPAGQT VLPPFFNGVI RSNSKPGDAF
AAAAAASRSI PAPRAAAIKS RRASSAVLQR ALETDASASI APPSRNDTNV SDKNLDTFGR
SGFLHEIGSE NIDLTSKEVS TVDAGQDNTS VAGDDVSEMD EFSNKSNLKE APNYTGSLVE
FPTRTEKDFI FNESSRLDEI EDRQVQSLSG GEDNVTSADS SEEAATNEIL SSPVYGSPSD
KTEKDGVKHE LENVISQSKE EETCSPRDEN DSLDDAASII EELVLQGESM RDSTTPLKKY
HSALKPLELA EEAEKKQAFT AMHLEEGAAA QPMRLDGVHR GSNVLGYFDV DDNNTITQTL
LSQAFRREHG SSQALAVHLN YIAVGMSRGS ILVMPSRYSP HHADDMDAKM LIFGLPRDRP
QVPVTSLSFN QQGDLLFAGY GDGHYTVWDV QRASVLKVVT EHKAPVVHLL YLGQDSQVTR
QFNVLSGDTK GVVKLSRFKV LPLINMISLS KSQEILTENN STTICAVPLL SGESYGGAMV
ASLDGGNPSL IEEGVVIFGT HQYALVAKIS PTFKVYAKIA RSDGVREGSM PYAAWKKCMG
SLSSSESMSI ETSENVSLLA IAWDQSVQVA KLVKSELKVC WKWTTDSSAV GLAWLDEQIL
VILTATGRLC LFSKDGNLIH QRSFALDGSC GDDVMSYHAY FSNAFGNPEK AHHNCLGVRG
ETLYILRPSQ LVVSRLLSWK ERIEVLHKGG DWTSALNMAM SLYDGRAQAV IDLPSNLDDV
QKILIPYLVQ LLLSYVDEVF SYIAVASGNQ HGQSGQSNES KYDADFVHPD IKEQYTVVGG
VSVEFCLHIK RLDVLFDEIF PKFDAVNHKD TFLELLEPYI LKDMLGSLPP EIMQALVEHY
STKGWLQRVE QCVLHMDMLS LDFNQVIRLC REHRLHGALI YLFNKGLDDF RTPLEELFLI
LRDSKRESAT TLGYKMLVYL KYCFQGLAFP PGRGTLPPTR VPSLKRELVQ FLLEEASSPN
SSTAMCLPYS GPHPNLLSLL ELDTEATLDV FRYAFVEGGN ESFSPAWNPA NLKTETTEVD
ILAIEGENLV QKVVDVLAAI LDMSYFQTGG SFNSKDERCT DIWPTKKDIE YILDFISFFI
TFEKATVSKD TLRQILEYLT LGNETYPNVS RRIVETFNRR QKQLTALLEV LPEEDWDAHY
LLNLCEKGQL HQVCGLIHAI RHQYLSALDS YMKAVDEPIL AFIFIDSMLR QPRGKESDAF
RSAVISRIPD LLKLNREGTF FLIVNHLGEE KDYILSQLRS NPESLFLYLK TLIEVHSTGT
LNFSSLRKDN ASDFRGSKRL MSSEVYLETL SDLPKLLQNY PIHITDEMTE LYIELLCRYE
PKSVLGFLET FESYRVERCL RLCQEYGIVD AAAFLLERVG DIGSALLLVI SSLNEKFILL
DTAVESKHSD AAPEHFKATL SKKEVTVILD ILRTCIGLCQ RNSPRLDPDE AESLWFQLLD
SKIRYKEEEC MQEGQQACKI QWKVSKSHRN AHILRKLLSV FIKEIIEGMI GYVSLPRIIL
KLLSDNETQE FGDFKPTILG MLGTYDFERR ILDTAKSLIE DDTYSSLSLL KRGASHGFAP
RSLLCCICNC PLTKDFSASS IQIFSCGHAI HLQCEPQGNE ASCRGNSAGC PICMPRKNSE
RLRSKSVLVE NGLVKTLSKS HQTHGMTALH PHENDGFDNF YGLQSISRFD LLLNLQKNNQ
SMQIENIPQL RLAPPAVYHE KVKKRNVPSA GESSNGLAKM EKPSRSKHLR DVKLKGSSLR
FPLKSKVFGK EKNIKL
//
