ID A0A1S3WYX9_TOBAC Unreviewed; 1872 AA.
AC A0A1S3WYX9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Vacuolar protein sorting-associated protein 8 homolog isoform X4 {ECO:0000313|RefSeq:XP_016432738.1, ECO:0000313|RefSeq:XP_016432739.1};
GN Name=LOC107759344 {ECO:0000313|RefSeq:XP_016432738.1,
GN ECO:0000313|RefSeq:XP_016432739.1, ECO:0000313|RefSeq:XP_016432740.1,
GN ECO:0000313|RefSeq:XP_016432741.1, ECO:0000313|RefSeq:XP_016432742.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016432741.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016432738.1, ECO:0000313|RefSeq:XP_016432739.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS8 family.
CC {ECO:0000256|ARBA:ARBA00009422}.
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DR RefSeq; XP_016432738.1; XM_016577252.1.
DR RefSeq; XP_016432739.1; XM_016577253.1.
DR RefSeq; XP_016432740.1; XM_016577254.1.
DR RefSeq; XP_016432741.1; XM_016577255.1.
DR RefSeq; XP_016432742.1; XM_016577256.1.
DR GeneID; 107759344; -.
DR OrthoDB; 120292at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR025941; Vps8_central_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12816; Vps8; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 484..518
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1697..1745
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1872 AA; 208552 MW; 55D1B1EF8CE7DC68 CRC64;
MELDLDSFLE SHADDDDDDH LLHHRTVDEI LLNHSSSSSS SSSSSSSPSP PSSPSAAHGH
NYLDRRSRSV DSSSQSAEPR PESISSKQSS EFFSPPAGQT VLPPFFNGVI RSNSKPGDAF
AAAAAASRSI PAPRAAAIKS RRASSAVLQR ALETDASASI APPSRNDTNV SDKNLDTFGR
SGFLHEIGSE NIDLTSKEVS TVDAGQDNTS VAGDDVSEMD EFSNKSNLKE APNYTGSLVE
FPTRTEKDFI FNESSRLDEI EDRQVQSLSG GEDNVTSADS SEEAATNEIL SSPVYGSPSD
KTEKDGVKHE LENVISQSKE EETCSPRDEN DSLDDAASII EELVLQGESM RDSTTPLKKY
HSALKPLELA EEAEKKQAFT AMHLEEGAAA QPMRLDGVHR GSNVLGYFDV DDNNTITQTL
LSQAFRREHG SSQALAVHLN YIAVGMSRGS ILVMPSRYSP HHADDMDAKM LIFGLPRDRP
QVPVTSLSFN QQGDLLFAGY GDGHYTVWDV QRASVLKVVT EHKAPVVHLL YLGQDSQVTR
QFNVLSGDTK GVVKLSRFKV LPLINMISLS KSQEILTENN STTICAVPLL SGESYGGAMV
ASLDGGNPSL IEEGVVIFGT HQYALVAKIS PTFKVYAKIA RSDGVREGSM PYAAWKKCMG
SLSSSESMSI ETSENVSLLA IAWDQSVQVA KLVKSELKVC WKWTTDSSAV GLAWLDEQIL
VILTATGRLC LFSKDGNLIH QRSFALDGSC GDDVMSYHAY FSNAFGNPEK AHHNCLGVRG
ETLYILRPSQ LVVSRLLSWK ERIEVLHKGG DWTSALNMAM SLYDGRAQAV IDLPSNLDDV
QKILIPYLVQ LLLSYVDEVF SYIAVASGNQ HGQSGQSNES KYDADFVHPD IKEQYTVVGG
VSVEFCLHIK RLDVLFDEIF PKFDAVNHKD TFLELLEPYI LKDMLGSLPP EIMQALVEHY
STKGWLQRVE QCVLHMDMLS LDFNQVIRLC REHRLHGALI YLFNKGLDDF RTPLEELFLI
LRDSKRESAT TLGYKMLVYL KYCFQGLAFP PGRGTLPPTR VPSLKRELVQ FLLEEASSPN
SSTAMCLPYS GPHPNLLSLL ELDTEATLDV FRYAFVEGGN ESFSPAWNPA NLKTETTEVD
ILAIEGENLV QKVVDVLAAI LDMSYFQTGG SFNSKDERCT DIWPTKKDIE YILDFISFFI
TFEKATVSKD TLRQILEYLT LGNETYPNVS RRIVETFNRR QKQLTALLEV LPEEDWDAHY
LLNLCEKGQL HQVCGLIHAI RHQYLSALDS YMKAVDEPIL AFIFIDSMLR QPRGKESDAF
RSAVISRIPD LLKLNREGTF FLIVNHLGEE KDYILSQLRS NPESLFLYLK TLIEVHSTGT
LNFSSLRKDN ASDFRGSKRL MSSEVYLETL SDLPKLLQNY PIHITDEMTE LYIELLCRYE
PKSVLGFLET FESYRVERCL RLCQEYGIVD AAAFLLERVG DIGSALLLVI SSLNEKFILL
DTAVESKHSD AAPEHFKATL SKKEVTVILD ILRTCIGLCQ RNSPRLDPDE AESLWFQLLD
SFCEPLMDSH DHSKIRYKEE ECMQEGQQAC KIQWKVSKSH RNAHILRKLL SVFIKEIIEG
MIGYVSLPRI ILKLLSDNET QEFGDFKPTI LGMLGTYDFE RRILDTAKSL IEDDTYSSLS
LLKRGASHGF APRSLLCCIC NCPLTKDFSA SSIQIFSCGH AIHLQCEPQG NEASCRGNSA
GCPICMPRKN SERLRSKSVL VENGLVKTLS KSHQTHGMTA LHPHENDGFD NFYGLQSISR
FDLLLNLQKN NQSMQIENIP QLRLAPPAVY HEKVKKRNVP SAGESSNGLA KMEKPSRSKH
LRDVKLKGSS LR
//
