ID   A0A1S3WZE8_TOBAC        Unreviewed;       443 AA.
AC   A0A1S3WZE8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Omega-6 fatty acid desaturase, chloroplastic-like isoform X1 {ECO:0000313|RefSeq:XP_016432928.1};
GN   Name=LOC107759483 {ECO:0000313|RefSeq:XP_016432928.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016432928.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016432928.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00009295}.
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DR   RefSeq; XP_016432928.1; XM_016577442.1.
DR   AlphaFoldDB; A0A1S3WZE8; -.
DR   STRING; 4097.A0A1S3WZE8; -.
DR   PaxDb; 4097-A0A1S3WZE8; -.
DR   GeneID; 107759483; -.
DR   OrthoDB; 311636at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045485; F:omega-6 fatty acid desaturase activity; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR   CDD; cd03507; Delta12-FADS-like; 1.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR32100:SF35; OMEGA-3 FATTY ACID DESATURASE FAT-1; 1.
DR   PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          144..392
FT                   /note="Fatty acid desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
SQ   SEQUENCE   443 AA;  51239 MW;  EF984F7A9960839B CRC64;
     MACSVADSGF LFLASKKRPI HSTRITQVAS SGTGTYFLKW ESLPQIRSKQ KSCLISLRKT
     NVVRAVAVPI APSPLDSAED RKQLSEMYGF RQIGEPLPHK VTMKDITETL PKKVFEIDNG
     KALKSVLISV TSYTLGLFMI AKAPWYLLPL AWAWTGTAVT GFFVIGHDCA HKSFSKNKFL
     EDIIGTLAFL PLIYPYEPWR FKHDRHHAKT NMLHEDTAWQ PVWKEEFDSV PALRKAIIFG
     YGPFRPWMSI AHWWLCHFNL KKFRPNEINR VKISLGCVFA FMAIGWPLII WKTGIIGWIK
     FWLMPWLGYH FWMSTFTMVH HTAPHIPFKN SDEWNAAQAQ LNGTVHCDYP SWIEVLCHDI
     NVHIPHHISP RIPSYNLRAA HQSLQQNWGK YLNEASWNWR LMKTILTICH VYDKEQNYVA
     FDEVVPEEAQ PITFLKKVMP DYA
//