ID A0A1S3X018_TOBAC Unreviewed; 924 AA.
AC A0A1S3X018;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107759809 {ECO:0000313|RefSeq:XP_016433310.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016433310.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016433310.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR RefSeq; XP_016433310.1; XM_016577824.1.
DR AlphaFoldDB; A0A1S3X018; -.
DR STRING; 4097.A0A1S3X018; -.
DR PaxDb; 4097-A0A1S3X018; -.
DR GeneID; 107759809; -.
DR KEGG; nta:107759809; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:XP_016433310.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transferase {ECO:0000313|RefSeq:XP_016433310.1}.
FT DOMAIN 363..924
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_016433310.1"
FT NON_TER 924
FT /evidence="ECO:0000313|RefSeq:XP_016433310.1"
SQ SEQUENCE 924 AA; 102734 MW; 66F356ED7573EB12 CRC64;
ITKVGDANMD VMSALITSLL RGCAEQSRTM VGQRLKLICA DCLGALGAID PSKVKGFSSM
RFQIACSDDD LIFELIHKHL ARAFRAAPDT IIQDSAADTI IQDSAALAIQ ELLKIAGCEA
SLDDNVVAST SQTRGKRPVK LLASVVDGNC TEMQERGQRL WNRFSSYVKE IIAPCLTSRF
QLPSMSDSAS SGPIYRPSMS FRRWIFFWIK KLTAHATGSR ASIFNACRGI VRHDMQIAMY
LLPYLVLNAV CDGTEEARCG ITEEILSVLN AAASENSTDV NGISSGHNEV CIQAVFTLLD
NLGQWVDDVQ QELSLSQSIQ TSSSRQQALK SKEKAINLSS DSNQVLIQCK HVSELLAAIP
KVTLARSSFR CQAYARSLLY FESHVREKSG SFNPASEKSG LFEDEDISFL MEIYSGLDEP
DGLCGFASLR KSKSLQDHLL INKKAGNWAE VLTSCEQALQ MEPTSVQRHS DVVNCLLNMC
HLQATVTHVD GLISRIPKYK KTWCMQGVQA AWRLGRWDLM DEYLSGADEE GLVCSSSESN
ALFDMDVAKI LQAIMKRDQF SIAKKITLSK QALIAPLAAA GMDSYARAYP FVVKLHMLRE
LEDYSSLLGG ESFLEKSFPL YDPNFSKLIE SWENRLKLTQ PSLWAREPLL VFRRLVFGAS
GLHAQVGECW IQYAKLCRSA GHYETASRAI LEAKASGAPN VHMEKAKLLW STRRADGAIA
ELQQTLLNMP VEVVGSAAIS SITSLSLVPL NPQPLRCGTQ SSNENRGVAK TLLLYSRWIH
YTGQKQKEDV ISLYSRVKEL QPKWEKGYFY LAKYCDELLV DARKRQEDKE PCSKAVPAKS
ALVAATNLNT EKSWLSYLPD VLLFYAKALH RGHRNLFQAL PRLLTLWFDF GSVYHISRSA
ANKEMKTIHG KVLSIMRGCL NDFP
//
