ID   A0A1S3X0D4_TOBAC        Unreviewed;       739 AA.
AC   A0A1S3X0D4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Formin-like protein {ECO:0000256|RuleBase:RU361260};
GN   Name=LOC107759859 {ECO:0000313|RefSeq:XP_016433357.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016433357.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016433357.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC       {ECO:0000256|ARBA:ARBA00025793}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_016433357.1; XM_016577871.1.
DR   AlphaFoldDB; A0A1S3X0D4; -.
DR   SMR; A0A1S3X0D4; -.
DR   STRING; 4097.A0A1S3X0D4; -.
DR   PaxDb; 4097-A0A1S3X0D4; -.
DR   GeneID; 107759859; -.
DR   KEGG; nta:107759859; -.
DR   OMA; PNVPANQ; -.
DR   OrthoDB; 623207at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR027643; Formin-like_plant.
DR   PANTHER; PTHR23213:SF273; FORMIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR23213; FORMIN-RELATED; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          276..710
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          115..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..224
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..281
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  83055 MW;  74F2F1E493E28EF6 CRC64;
     MNAPGPPLTH SSQNQVVLKA VIAAVVTTLI IAGILFYFFY RYYIARQRKR NKLNSSFRRE
     VSGSALHQEF QQSGALKGLI VDENGLDVIY LRKFEGRQLG SCFSKVWVNY IDGEEEKRTD
     SRREKPVSRD QIQEIPLLQN ASNVDGYEKE ADTAQQTINS LPAASRSSQH PYPQFPSSSL
     QFPQKEITPQ SVIPSQPAVL SSQNPPQPPR PPPPPPPLPM KRIIKAPTPP NAAKIKPSPP
     PLPKGNGLHS SLKPPVAPRE KASSQEKTEA PTDEKSKDDG EVQIKLRPLH WDKVIANTDH
     SMVWDEINNG SFRFEDDLME VLFGYNITSQ KTPEGNNTTT SSGTSKLARP AQIFILDPRK
     SQNTAIVLKS LSISREEIVD ALLEGQGLSV DTLEKLTKIC PTEEETLKIL QFDGDPRKLA
     DAESFLHHML KAVPSAFKRF NAMLFRSSYD SEILILKENL QTVEQGCKEL RTCRIFLRLL
     EAILKAGNRM NAGTARGNAK GFNLGALQKL SYVKSNDGKT TLLHFVVEQV IHSEGKRRLI
     NKGSKVDNED FDRKTEKLEK DTEHLILGLP VLQGLSFEFS NVKKAATMDY DSFINTCSTL
     TMRINDVRQL IKCCGNAERD RFVKVTKGFL EECEEELKVI REEQTRVMEL VKRTTEYYQA
     GSSKDKGTQA LQLFAIVKDF LDMVDKVCID ITKKVQKKNA SSVESPPPQS TIPRTPVRFH
     NLRTYFTPEI LSSESENEF
//