ID A0A1S3X5W7_TOBAC Unreviewed; 718 AA.
AC A0A1S3X5W7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN Name=LOC107761649 {ECO:0000313|RefSeq:XP_016435380.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016435380.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016435380.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
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DR RefSeq; XP_016435380.1; XM_016579894.1.
DR AlphaFoldDB; A0A1S3X5W7; -.
DR SMR; A0A1S3X5W7; -.
DR STRING; 4097.A0A1S3X5W7; -.
DR PaxDb; 4097-A0A1S3X5W7; -.
DR GeneID; 107761649; -.
DR KEGG; nta:107761649; -.
DR OMA; STPHPCQ; -.
DR OrthoDB; 1396at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0009507; C:chloroplast; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR PANTHER; PTHR21262:SF0; GTP DIPHOSPHOKINASE RSH3, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 241..345
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 108..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 79548 MW; 3164AA8829A2FC04 CRC64;
MAVPTIALYA SPPSSVCSTP YPCQINSHGS YDFDLNGRSS SSSSTSSSSG KSFVGGLSSL
FSSPTVKANY STGTEDLGSL WHDRGDELSS SFRCSSLSSS LKRDQSPVSV FQGPASTSSS
GIGSCSRSPP RRIAGDVGSI RSGTGGLFNG FVRHALGSCV DHDPTTFRVL DVDSPSSGLL
DELTFNMEEG FLESNSEPYA KDLLLNAQSR HKIFYDDFVI KAFYEAEKAH RGQVRASGDP
YLQHCVETAV LLAMIGANST VVAAGLLHDT LDDTFMTYDY IFRTLGAGVA DLVEGVSKLS
QLSKLARDFN TASKTVEADR LHTMFLAMAD ARAVLIKLAD RLHNMMTLDA LPLAKQQRFA
KETLEIFAPL ANRLGISTWK EQLENLCFKH LNPDQHNELS SKLVKSFDEA MITSSVGKLE
QALKDDSVSY HVLSGRHKSL YSIYCKMLKK KLNMDEVHDI HGLRLIVENK EDCYKALRVV
HQLWSEVPGR YKDYIANPKF NGYQSLHTVV LGEGMVPLEV QIRTKEMHLQ AEYGFAAHWR
YKEGACKHSS FVNQMVEWAR WVVTWQCETM NRDQSSVGHT ESIQPPCKFP AHSEDCPFSC
KPNCGTDGPV FIIMIDNDKM SVQEFPANST VKDLLERAGR GSSRWTPYGF PLKEELRPRL
NHEPVSDPNC KLRMGDVIEL TPAIPHKSLT EYREEIQRMY DRGVSPLPAA NAVVGLRS
//
