ID A0A1S3XDQ8_TOBAC Unreviewed; 1243 AA.
AC A0A1S3XDQ8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC107764075 {ECO:0000313|RefSeq:XP_016438086.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016438086.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016438086.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_016438086.1; XM_016582600.1.
DR AlphaFoldDB; A0A1S3XDQ8; -.
DR STRING; 4097.A0A1S3XDQ8; -.
DR PaxDb; 4097-A0A1S3XDQ8; -.
DR GeneID; 107764075; -.
DR KEGG; nta:107764075; -.
DR OMA; HELTETG; -.
DR OrthoDB; 760200at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF305; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 4..181
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1243 AA; 142961 MW; 4E3FFF0E3B2773D5 CRC64;
MSQFVHHVFL SSRSKEVSNT FGDHLQTALV NAGIRAFKFD EELVEEEEHQ KKVQKVIQEY
RILIVVFSKD YASSQNCLDE LVYILESKKA FGHFVLPVFY DVDPSQVRKQ KGCFEEAFFR
YEERYKTEND ERRKEWMEKV DKWRAAFREV ADLGGMVLQN QADGYESRFI QEIVKVVASK
LNRTILSVAL HPIGIDSRVK DLNLWLQEES TTVDILAIHG MAGIGKSTIA KTVYNLNFDR
FEGSSFLADV RKALEKYDGL ARLQRQLLSN ILGKNVEKLY NVNEGAVKIQ EAISCKKVLV
VLDDVDELDQ LNAVIGMRQL FYPGSKIIIT TRNGHLLNSS EACRCKMYKL NSLDARESLQ
LFSWHAFGAK YPPLDYMNLS TDVIVHCQGI PLALKVLGSS LCDRSTEVWE SALRKLKAIP
DSKILEKLRI SYECLPDDNV QNLFLDIIYF FVGKDKDYAV TILDGCGFFS VVGIQILIDR
CLLAVTDKKK LMVHQLLQDM GREIIRQESP REPWKRSRIW LHKESFNILQ AKTGTENIQG
LVLDMRLLKE VKYIGSNLSV NDARHNRSND PAGERSLVVS DVNSQKQRRL TVFELFTNVF
SEISNGVQFE LDAFSKMKRL RILQLTDTRF TGSYSWFPEN LRSLHWHGFY LKFIPKDFPL
ESLVALDMRK SKLEQAWDGT RVLKQLKVLN LSHSHFLRRT PDFSGLPNLE RLILKDCIRL
FSIHESIGDA KALVLFNLRD CKNLRNLPRS FCKLKSLETL IISGCSRLSI STMELGKLEF
LTTLKADEIS YNQEKSWTEL WQSWSSRLRK SPDYNNFSLS SLSSSLVSLS LAKCRLTDDF
LSLGLCNLSS LRHLNLSENL ICNLPQNITN LNMLQELWLD ACPSLQSLPK LPPSLIKLKA
IDCTSLERVT NLPNLWETQT LLLDVRGSEK LTEIPGLFKL EPVGNFKGEM LNILSHLNLE
DIENAEVELF NRLTDTKRKY SVQGLYEFGI FSTYFPGSDI PSWFSNKGEE SILTLKVDSH
TNTKIIGLNI CIVYSRSTRH RFQRWGENQF GNWYSFFIKL SNVISGDKWI YAPTFIGIPG
SNEDLTFLCH WKFGKYIQAG DEINVSVLGW SYTFQMKEFG ASIECDRPET DQHLTSTSES
KELAIQHRYP SSSMQEQCVM GSYMPIYQVA ARHYYFSHPD YFLPKSNEHA AVRSILYENL
FEDFVHRTTD AGAEDDSDFD FDEENYTEEA ALAELEDNLE WPW
//
