ID A0A1S3XIE9_TOBAC Unreviewed; 989 AA.
AC A0A1S3XIE9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN Name=LOC107765589 {ECO:0000313|RefSeq:XP_016439745.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016439745.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016439745.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
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DR RefSeq; XP_016439745.1; XM_016584259.1.
DR AlphaFoldDB; A0A1S3XIE9; -.
DR SMR; A0A1S3XIE9; -.
DR STRING; 4097.A0A1S3XIE9; -.
DR PaxDb; 4097-A0A1S3XIE9; -.
DR GeneID; 107765589; -.
DR KEGG; nta:107765589; -.
DR OMA; HEMFLFG; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 107..260
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 324..977
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 989 AA; 111450 MW; 6B54828653215A21 CRC64;
MDDLEKAILI SFDESGAVDS ALKVQAVAYC QQFKETPSIC SICIERLCFS KLVQVQFWCL
QCLHEVLRVR YSSMGPEEKS FIRKSVFSLG CYESIDDKNL VRVLDGPAFI KNKLAQVIVT
LIYFEYPMIW PSVFVDFLSN LSKGVVVIDM FCRVLNALDD EVISMDYPRS QEEVSVSGRI
KDAMRQQCIS QVVRAWYDIL LMYRNSDPDL CCSVLDSMRR YVSWIDIGLI ANDTFVGLLF
ELTLASGFHD QLSGAAAGCI HAVAAKRMDP KAKLTLLQSL QIRRVFSLVA EDNDSELVSS
VASLLTGYST EVLECLKRLN SEDGKALSTE LLNEVLPSVF YVMQNCEIDE TFSIVQFLSG
YVGTLKSLVP LTETQSHHVG QILEVIRSQI RFDPAYRNNL DVLDKIGREE EDRMAEFRKD
LFVLLRSVGR VAPDATQIFI RNSLASAVAS NGDVDVEEIE AALSLLYAFG ESLTDETMKT
GNGLLGELIP MLLSTKFPCH NNRLVALIYL ETVTRYMKFF QENTQYIPLV LSAFLDERGI
HHPNSNVSRR ASYLFMRVVK LLKAKLVPYL ETILQSLQDT VAQFTTIYAS SKELSGCEDG
SHIFEAIGLL IGMEDVPLEK QSEFLSALLT PLCQQVEALL LNAKAQNPEE SPAKIANIQQ
IIMAINALSK GFSERLVTAS RPAIGLMFKQ TLDVLLRILI IFPKIEPLRC KVTSFIHRMV
DILGSSVFPY LPKALEQLLA ESEPKELAGL LVLLNQLICK FNTGVRDILE EVYPAIASRV
FNVLPRDAFP TGPGSNTEEI RELQELQRTF YTFLHVIATH DLSSAFLSSK SRVYLDPMMQ
LVLRASCNHK DIVVRKACVQ IFIKLIKDWC ARPYGEEKVP GFRSFVIEAF ATNCCLYSVL
DKSFEFRDAN TLVLFGEIVM AQKVMYEKFG NDFLVHFVSK GFPSAHCPQD LAEQYCQKLQ
GNDIKALKSF YQSLIENLRR QQNGSLVFR
//
