ID A0A1S3XTM0_TOBAC Unreviewed; 1171 AA.
AC A0A1S3XTM0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=TMV resistance protein N-like {ECO:0000313|RefSeq:XP_016443215.1};
GN Name=LOC107768608 {ECO:0000313|RefSeq:XP_016443215.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016443215.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016443215.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016443215.1; XM_016587729.1.
DR AlphaFoldDB; A0A1S3XTM0; -.
DR SMR; A0A1S3XTM0; -.
DR STRING; 4097.A0A1S3XTM0; -.
DR PaxDb; 4097-A0A1S3XTM0; -.
DR GeneID; 107768608; -.
DR KEGG; nta:107768608; -.
DR OMA; HQTWEGA; -.
DR OrthoDB; 766469at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF236; TMV RESISTANCE PROTEIN N-LIKE; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 16..190
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 553..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1171 AA; 133278 MW; AFED77902BC41F4B CRC64;
MFMMRAEKAS FSSPRCPYHV YLSYRGQEIS MNFINLLHTE LTRVGLRTFK KHGEARKGKI
VGSELQKAFK EARISIIVFS EDYAYSRRCL DELVNILERK FSAGHMILPV FYHMDPSHVR
KQKGSYAKAL HNYEEQIMGG KGERRNEQIA KVKIWRASLK EVANMAGIVL EDGDELTFIQ
EIVEDIWGKM SRKVLSIAQY PVGIYHRVKE ISFWLQDSLT GAHTLMIYGE PGIGKTTIAR
ALFNLHCDRF QYSSFLANIR EIAKESSSLI SLQKNLLSDL LKEDRIDLYD IDGGASKIKE
FLVHRRFLLV LDDVDDLDQL KALLDSRDWI PPGSKVIITT TNKSLVNPHD ACVMYEAKRF
DIPEALQLFS LHTFGQDHPA KEYMMQSKQI VKHCRGVPLA LQVLASSLRG GSIDLWEAAI
NKLERYSEFH KHKILELSYE ALPDDHEKNV FLDIACFFVG KDKDYTIKIL DECGFHATAE
IQNLIDRCLL TVTPENKLMM HQLLQEMGKE VICRESPTEP GKRSRIWHHK DALSILQEET
VTESIEGLTL KMRGSDESKS DKHENMSKRP HCDDSPNTST LILKNSSKRL CLRFFSWRQV
NSVSARSQTA PNEAGISSKA FFKMQELRFL ELDNVQLSGT YEGFPKKLRW MCWYQFQLTS
FPSGFPLENL VVLEMSNSNL HQTWEGAKSL RSLKILDLSH SRHLMKTPDF SGLPSLERVI
LEHCIGLVKV HESIGRLHKL LVLNLKGCES LRKLPRKMRE IKSLEELTLC GCSKLEFSTT
MRNQFFLQAL LQNVTNRNQL ASKGEKPICS DSLAAKSVYS IFWSWMSPWP KSARSMSELF
QITLQSLDIS HCNLTGTFIP YDLSVLSSLK YLNLRGNPIT TLPESLKSLT VLQSLQLADC
TKLQWIPELP LSLQLLNARN CISLNRVTNL PNFMRSLDLH LENCGNLVEV QGVFKLDPID
DIVVVSCLDN LEVRAVDVEL CNYLTSTKSK GPVQGLYEFG IHSIFIPGGK VPTEFNNIST
GSSLAFSVPQ LPNIKTQGLE ICIAYVECYD ECFSQSHFIK VSNKTKRIKW NYGPTVFGIA
TPGNPMLWLS RWKFGDQLEK GDQVVVSLSM SCLVREFGAH LVCSEQREED TLSENTKEGC
RRPCYPLHHA IGGDLSPYEL SSGVYHLSIY S
//
