ID A0A1S3XTV1_TOBAC Unreviewed; 496 AA.
AC A0A1S3XTV1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
GN Name=LOC107768744 {ECO:0000313|RefSeq:XP_016443373.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016443373.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016443373.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine =
CC H(+) + phosphocholine + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:25325, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:58641, ChEBI:CHEBI:59789, ChEBI:CHEBI:295975;
CC EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035588};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25326;
CC Evidence={ECO:0000256|ARBA:ARBA00035588};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-methylethanolamine phosphate + S-adenosyl-L-methionine =
CC H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:25321, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57781, ChEBI:CHEBI:57856, ChEBI:CHEBI:58641,
CC ChEBI:CHEBI:59789; EC=2.1.1.103;
CC Evidence={ECO:0000256|ARBA:ARBA00035580};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25322;
CC Evidence={ECO:0000256|ARBA:ARBA00035580};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-
CC methylethanolamine phosphate + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:20365, ChEBI:CHEBI:15378, ChEBI:CHEBI:57781,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:58190, ChEBI:CHEBI:59789;
CC EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035571};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20366;
CC Evidence={ECO:0000256|ARBA:ARBA00035571};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis;
CC phosphocholine from phosphoethanolamine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00035631}.
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DR RefSeq; XP_016443373.1; XM_016587887.1.
DR AlphaFoldDB; A0A1S3XTV1; -.
DR SMR; A0A1S3XTV1; -.
DR STRING; 4097.A0A1S3XTV1; -.
DR PaxDb; 4097-A0A1S3XTV1; -.
DR GeneID; 107768744; -.
DR KEGG; nta:107768744; -.
DR OMA; YKCIETY; -.
DR OrthoDB; 710013at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0000234; F:phosphoethanolamine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR025771; Phosphoethanolamine_N-MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR44307:SF13; PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 1-LIKE; 1.
DR Pfam; PF13489; Methyltransf_23; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS51582; SAM_PEAMT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 62..157
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT COILED 434..461
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 496 AA; 56184 MW; 2B51A5ACD0FE8CC4 CRC64;
MAAIDIAAAP EQEREIQKSY WIEQAAELTL KAMMLDSEAS DLDKEDRPEV LSLLPPYEGK
SVLELGAGIG RFTGGLAEKA GQLTTLDFVE DVIKKNESIN GHHKNVKFMC ADVTSPDLTF
SPESVDLIFS NWLLMYLSDK EVQDLAERMV KWLKVGGYIF FRETCFNQSG DNKGKNNPTH
YREPRFYTKV FNECNLNDDA GKSCELSLIG FKCIGAYART KKNQNEICWI WQKVHSADDR
GFQHFLDTVQ YKSNGILRYE RVFGHSFVST GGIDTTKEFV AMLDLQPGQK VLDVGCGIGG
GDFYMAEKYD VYVVGIDLSV NMISLAFERA IGRKCAVEFE VADCTKATYP EGTFDVIYSR
DTILHIQDKP ALFRSFYKWL KPGGKVLISD YCKRAGPASE EFAGYIKQRG YDLHDVEAYG
QMLRDAGFNE VVAEDRTEQF IKVLQKELDT VEKERESFIQ EFSEQDYNDI VGGWKAKLIR
STSSGEQRWG LFIAKK
//
