ID A0A1S3YI12_TOBAC Unreviewed; 1271 AA.
AC A0A1S3YI12;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Brefeldin A-inhibited guanine nucleotide-exchange protein 1-like {ECO:0000313|RefSeq:XP_016451891.1};
GN Name=LOC107776500 {ECO:0000313|RefSeq:XP_016451891.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016451891.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016451891.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_016451891.1; XM_016596405.1.
DR AlphaFoldDB; A0A1S3YI12; -.
DR SMR; A0A1S3YI12; -.
DR STRING; 4097.A0A1S3YI12; -.
DR PaxDb; 4097-A0A1S3YI12; -.
DR GeneID; 107776500; -.
DR KEGG; nta:107776500; -.
DR OMA; DLYITFF; -.
DR OrthoDB; 296747at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032817; Mon2_C.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF108; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16206; Mon2_C; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 105..292
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_016451891.1"
SQ SEQUENCE 1271 AA; 142394 MW; B4D6AB0E4FFDEC91 CRC64;
LIPSDICRTV NGLLKTALGP PPGSTTTLSP VQDITFRSES VKCLVTIIKS MGTWMDQQLK
VGDPNLDKVS DHEVPEAATS VSEEGNIIDY ELHPEANSEF SGAAALEQRR AYKLEIQKGV
SLFNRKPSKG IDFLMSTKKL GNSAEDVASF LKNTTGLNPS IIGDYLGERE EFPLKVMHAY
VDSFNFEGMD FGESIRYFLR GFRLPGEAQK IDRIMEKFAE RYCKCNPNSF TSAETAYVLA
YSVIMLNTDA HNSMVKDKMT KADFIRNNRG IDDGKDLPED YLGALYDQIV KNEIKMNADS
SVPQNKQGNS LNKLLGLDGI LNLVWKQREE KPLGANGVLV RHIQEQFKTK SGKSESIYYV
IADPAILRFM VEVCWGPMLA AFSVTLDQSD DKNATSQCLL GFRHAVHITA VMGMQTQRDA
FVTSMAKFTY LHCAADMKQK NVDAMKTIMS IAIEDGSHLH EAWEHFLTCL SRFEHLQLLG
EGAPSDSSFF TTSNSESEEK TLKSAGFPSL KKKGTLQNPT VAAVVRGGSY DSATVGANSP
VLVTPEQINN FISNLNLLDQ IGNFELNHIF AHSQRLNSEA IVAFVKALCK VSMSELQSPT
DPRVFSLTKI VEVAHYNMNR IRLVWSHIWS VLSEFFVAVG LSENLSVAIF VMDSLRQLAM
KFLEREELAN YNFQNEFLRP FVIVMQKSNS AEIRELIVRC ISQMVLSRVN NVKSGWKSVF
MVFTAAAADE RKNIVLLAFE TMEKIVREYF RYITETETLT FTDCVRCLIT FTNSRFNSDV
SLNAIAFLRF CAVKLAEGGL VSNEKNNNND SSIPVAEDEA SDGMFFTDKD DYMSFWEPLL
TGLSRLTSDP RSAIRKSALE VLFNILKDHG HLFPHLFWIN VFKSVIYPIF SPVNDSTEAQ
VKYDQSSFKS RYIPLDGCLW DSETSVAAAQ CLVDLFVNFF GMVRSELPSV VSIMVGFIKG
SGKDPATTGV ASLMRLAGDL GGKFREEDWK VIFLALKEAS NSTLPNFPKL LRTMDGIEIP
ISQSDNDMEF SSGAGLINDE SEDDNLHTAR YVVSRMKDHI AAQLRIIQVS SDLYKMCRRS
VSADTINILL GIYSSVTSHA QQLKSEKGVQ VKLQKACSIL EIPEPPLVYF ENESYQNYLN
FLHGLLVNNS SLVEKRNIET ELVGVCEEIL RVYLDCAGLN SVKRKPDDKA TYLWNLPLGS
AKKEELVART PLVLSVLRIL CSWQSDSFRR YISQLFPLMV DLVRSEHSSG EVQRELSHFF
QSCIGPIIMK L
//
