ID A0A1S3YU77_TOBAC Unreviewed; 342 AA.
AC A0A1S3YU77;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Homeobox-leucine zipper protein {ECO:0000256|RuleBase:RU369038};
DE AltName: Full=HD-ZIP protein {ECO:0000256|RuleBase:RU369038};
DE AltName: Full=Homeodomain transcription factor {ECO:0000256|RuleBase:RU369038};
GN Name=LOC107779587 {ECO:0000313|RefSeq:XP_016455522.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016455522.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016455522.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor. {ECO:0000256|RuleBase:RU369038}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000256|ARBA:ARBA00025748, ECO:0000256|RuleBase:RU369038}.
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DR RefSeq; XP_016455522.1; XM_016600036.1.
DR AlphaFoldDB; A0A1S3YU77; -.
DR SMR; A0A1S3YU77; -.
DR STRING; 4097.A0A1S3YU77; -.
DR PaxDb; 4097-A0A1S3YU77; -.
DR GeneID; 107779587; -.
DR KEGG; nta:107779587; -.
DR OMA; EEPGHHA; -.
DR OrthoDB; 450969at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; HOMEOBOX-LEUCINE ZIPPER PROTEIN; 1.
DR PANTHER; PTHR24326:SF621; HOMEOBOX-LEUCINE ZIPPER PROTEIN; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transcription {ECO:0000256|RuleBase:RU369038};
KW Transcription regulation {ECO:0000256|RuleBase:RU369038}.
FT DOMAIN 48..108
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 50..109
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 163..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 163..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 38842 MW; 1111B323960ABCFB CRC64;
MKRPCSSDSL GALMSMCPNT TDEQNHMYST RDFQSMLLDE EGCIEESGHV SEKKRRLSVE
QVKALEKNFE VENKLEPERK VKLAQELGLQ PRQVAVWFQN RRARWKTKQL ERDYGVLKAN
FDALKHNYES LKHDNEALLK EIRELKSKVY TENGENRGVA VKEEAMESES DDNKVIELSK
PNDNDINNNN LLENFEEEED EEEEINFENF NAAAASTNIF GDHFKDGSSD SDSSAILNED
SSPNAAAISS SGAFLISTNG NGSGSSKSST SLNFCFQFTE SSSKSNLGDG QKGNNYYQPQ
QYVKMEEHNF FNGEESCSTL FTDEQAPTLQ WYCPEDWNWK ES
//
