ID A0A1S3YWE0_TOBAC Unreviewed; 757 AA.
AC A0A1S3YWE0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC107780339 {ECO:0000313|RefSeq:XP_016456350.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016456350.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016456350.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR RefSeq; XP_016456350.1; XM_016600864.1.
DR AlphaFoldDB; A0A1S3YWE0; -.
DR SMR; A0A1S3YWE0; -.
DR STRING; 4097.A0A1S3YWE0; -.
DR PaxDb; 4097-A0A1S3YWE0; -.
DR GeneID; 107780339; -.
DR KEGG; nta:107780339; -.
DR OMA; XVITKLA; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IBA:GO_Central.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF17; DNA HELICASE; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|RefSeq:XP_016456350.1};
KW Helicase {ECO:0000313|RefSeq:XP_016456350.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|RefSeq:XP_016456350.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 274..438
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 493..637
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 757 AA; 86207 MW; 79A8C30BBB80B753 CRC64;
MGIGEKGRLN KKIKFSIRPT IIESEDEEEE NGDNYFDSEL LIYDSDNKGV ELLRDFTKLE
LKPDHENRPL WVCSDGRVFL ETFSPLYKQA SDFLIAIAEP VSRPQSIHEF NLTPHSLYAA
VSVGLHTHTI ISVFNKLSKT KLPEEVVDFI QASTSNYGKV KLVLKQNRYL IESPYAEVLE
KLLMDDVISR ARIASSDLGL LSELTSEEKE TRYSFEIDSA QVESVKQRCL PNALNYPMLE
EYDFRNDTVN PDLDMELKVN AQPRPYQEKS LSKMFGNGRA RSGIIVLPCG AGKSLVGVSA
ATRIKKSCLC LATNAVSVDQ WAYQFRLWST IRDEQICRFT ADSKEQFRRD IAAGVVVTTY
NMIAFGGKRS EESDKLIEEI RNREWGLLLL DEVHVVPAQM FRKVISLTKS HCKLGLTATL
VREDERITDL NFLIGPKLYE ANWSDLAKGG FIANVQCAEV WCPMTKEFFA EYLKQENQRK
RQALYVMNPN KFRACEFLIR FHEQQRADKI IVFSDNLFAL MEYAMKLRKP MIYGGTSHAE
RMKILEAFRT SPEVNTIFLS KVGDNSIDIP EANVIIQISS HAGSRRQEAQ RLGRILRAKG
RPRGRSGIEE HDAFFYSLVS TDTQEMYYST KRQQFLIDQG YSFKVITSLP PPDSGPELSY
YHVEEQLGLL GKVLSAGEDM VGLEEIEEEE EEDTDGKALR RANRSVGSMS TYSGAKGMIY
MEYNGDQKKP GVGGLVQTKS KPKDLSKRHF LFKKRYV
//
