ID A0A1S3YXS4_TOBAC Unreviewed; 1141 AA.
AC A0A1S3YXS4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107780809 {ECO:0000313|RefSeq:XP_016456885.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016456885.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016456885.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000256|ARBA:ARBA00008684}.
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DR RefSeq; XP_016456885.1; XM_016601399.1.
DR AlphaFoldDB; A0A1S3YXS4; -.
DR GeneID; 107780809; -.
DR OMA; GARHNRI; -.
DR OrthoDB; 1080534at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27008; OS04G0122200 PROTEIN; 1.
DR PANTHER; PTHR27008:SF438; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 5.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_016456885.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|RefSeq:XP_016456885.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1141
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010353550"
FT TRANSMEM 781..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 840..1120
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 879
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1141 AA; 126519 MW; 50F49B2D37735D2A CRC64;
MEKSYSFVLS VVFELYFLVA CMATNITTDQ SALLALKSSF ALNSSHPLTQ NWSSQASVCN
WIGISCGSHH HRVTALNISN MNIHGTIPPQ LGNLSFLVSL DVSKNNFDGD FPQDLSRVRR
LREIDLGYNN FSGEIPIWFG LFSKLKMLIL DDNAFTYIPP SISNLSKLET LSAGYNRLQG
NIPKEIGNLQ NLKELVLVSN QLTGSIPFSI LNISSLETLA LTYNQLSGSL PVDICSRLQR
IKSISIISNQ LSGHIPEGLS NCSELYDLAL SYNKLSGTIP PELGKLEMLE LLSLGGNNLE
GIIPDTIGNL RKLQKLQLEN NHLVGSIPRT IFNMSSLWLL NFNTNNLSGV IPREIGNLQK
LELLYLQFNK LSGSLPEELF NISTLRGMAL SYNNFSGSLP SALGYWPTTL QYLHLGENNI
GGVIPNSVFN SSNLKELILD DNRFSGAIPN SLGDLRQLER LRLFRNNLTF PQLSIFASLA
NCRSLREIDL SDNPLNGVLS DSIGNLSTSL ELFDLRHSEI SGQIPLGIGN LSNLTDLYLL
DNDLTGSVPS TFCDLHNLQR LYLHQNRLIG PLPECLCNLP VLGMVSLSYN QISGPIPYCI
GNVTSLRNIY LNSNRLTKIP MSLWSLKDLV ELDLSNNSLV GSLPPDFGNL NAITFLDLSR
NHISGSVPST VGDLQKLLYL SVAYNELQGS IPESLGKMLS LESVNLSNNY LSGMIPKSLE
ALQYVKHFNV SFNRLEGEIP SKGPFVNFTS QSFMGNEELC GGFLFLPCKN RSVHQSRRNK
VLLIVLIPLA VLLMGLGSII LFMLKRRGNR NIPTQVESLP ATTTPTRISY IEIERATQGF
DQCNLLGRGG FGSVYKGMFS NGMVLAIKVF TLQSEVAFKS FDLECEVLRN LRHRNLTKVI
SSCSNMDFKA LLLEYMPNGS LEKWLHSDDY FLDIIQRLDV MIDVASALEY LHHGCSTVIV
HCDLKPSNVL LDEKLVGHVS DFGMAKLLGE GESIVHTKTL ATMGYIAPEY GSVGLVSTSC
DVYSYGIMLM ETFTRKNPYN EMFQENLSMR SWVCNSLPVA PEDIIDVSLL ESEKIGFKKK
LHCVSAILEL ALNCTAESPN ERLNMKDILA NIKKIKLAFL RECDDAPNMP FLLNPKQKRG
G
//
