ID A0A1S3Z6B3_TOBAC Unreviewed; 354 AA.
AC A0A1S3Z6B3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Cathepsin B-like {ECO:0000313|RefSeq:XP_016459757.1};
GN Name=LOC107783298 {ECO:0000313|RefSeq:XP_016459757.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016459757.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016459757.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_016459757.1; XM_016604271.1.
DR AlphaFoldDB; A0A1S3Z6B3; -.
DR SMR; A0A1S3Z6B3; -.
DR STRING; 4097.A0A1S3Z6B3; -.
DR PaxDb; 4097-A0A1S3Z6B3; -.
DR GeneID; 107783298; -.
DR KEGG; nta:107783298; -.
DR OMA; DEKIPYW; -.
DR OrthoDB; 808912at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR012599; Propeptide_C1A.
DR PANTHER; PTHR12411:SF908; CATHEPSIN B-LIKE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR Pfam; PF08127; Propeptide_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..354
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018578415"
FT DOMAIN 98..333
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 354 AA; 39145 MW; FEA4139630818AC9 CRC64;
MNHMALATLL LLIGASIVVL QVVAEQPISQ AKAESAILQD AIIKQVNENE KAGWKAALNP
RFSNFTVSQF KRLLGVKPTR KGDLKGIPIL THPKLLELPQ EFDARVAWPN CSTIGRILDQ
GHCGSCWAFG AVESLSDRFC IHYGLNISLS ANDLLACCGF LCGDGCDGGY PLQAWKYFVR
KGVVTDECDP YFDNEGCSHP GCEPAYPTPK CHRKCVKQNL LWSRSKHFGV NAYMISSDPH
SIMTEVYKNG PVEVSFTVYE DFAHYKSGVY KHVTGDIMGG HAVKLIGWGT SEDGEDYWLL
ANQWNRGWGD DGYFKIRRGT NECEIEDEVV AGLPSARNLN VELDVSDAFL DAAM
//
