ID A0A1S3Z7E1_TOBAC Unreviewed; 1116 AA.
AC A0A1S3Z7E1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=LOC107783768 {ECO:0000313|RefSeq:XP_016460274.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016460274.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016460274.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_016460274.1; XM_016604788.1.
DR AlphaFoldDB; A0A1S3Z7E1; -.
DR SMR; A0A1S3Z7E1; -.
DR STRING; 4097.A0A1S3Z7E1; -.
DR PaxDb; 4097-A0A1S3Z7E1; -.
DR GeneID; 107783768; -.
DR KEGG; nta:107783768; -.
DR OMA; HTAHHRF; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF921; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW ECO:0000313|RefSeq:XP_016460274.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 52..177
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 197..521
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..562
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1116 AA; 130591 MW; F72C88043874ACF8 CRC64;
MTLLTPPPID PEEHEMLVPS SDFPTEGPQP MEVAPADTAS TVDAQAVDDP ASARFTWTID
NFSRLNVKKL YSDVFNVGGY KWRILIFPKG NNVDNLSMYL DVADSATLPY GWSRHAQFSL
AILNRIHNKF TVRKDTQHQF NARESDWGFT SFMPLSELYD PGRGYLVDDA VIVEADVAVR
KVIDYWSHDS KKETGCVGLK NQGATCYMNS LLQTLYHIPY FRKAVYHMPT TENDNPSGSI
PLALQSLFYK LQYSDTSVST KELTKSFGWD TYDSFMQHDV QELNRVLCEK LEDKMKGTVV
EGTIQQLLEG HHMNYIECIN VDYKSTRKES FYDLQLDVKG CRDVYASFDK YVEVERLEGD
NKYHAEQHGL QDARKGVLFI DFPPVLQLQL KRFEYDFARD AMIKINDRYE FPLQLDLDRE
NGKYLSPDAD RSVRNLYTLH SVLVHSGGVH GGHYYAYIRP TLSDQWYKFD DERVTKEDTK
RALEEQYGGE EELPHTNPGF NNSPFKFTKY SNAYMLVYIR ESDKEKIICN VDEKDIAEHL
RIRLKKEQEE KEQKRKEKAE AHLYTIIKVA RDEDLGEQIG KEIYFDLVDH DKVRSFRIQK
QMPFTQFKEE VAKELGIPVQ FQRYWLWAKR QNHTYRPNRP LTAQEEVQSV GQLREVSNKA
NNAELKLFLE VEFGLDLQPF PPSQKTKEDI LLFFKLYDPL KEEIRYVGRL FVKGSGKPHE
ILTKLNELAG FLPDEEIELF EEIKFEPNVM CERIDGKLSF RGSQLEDGDI ICFQKSLRNQ
DREQYRFPEV PLFLEYVHNR QVVRFRSLEK PKEDEFSLEL SKKNSYDEVV EHLARHLGLD
DASKVRLTSH NCYSQQPKPQ PIRYRGVDRL TEMLSHYNQT SDILYYEVLD IPLPELQGLK
ALKVTFHHAA KDEVTIHTIR LPKQSTIGDV LNDLKTKVEL TRPDAELRLL EVFYHKIYKI
FPLNERIENI NDQYWTLRAE EIPEEEKNLG PHSRLIHVYH FMKDTSQNQA QIHNFGDPFF
LVIHEGDTLT EVKARIQKKL QVPDEEFSKW KFAFLSMGRP EYLEDSDVVS NRFQKRDVYG
AWEQYLGLEH IDNAPKRSHA ANQNRHTFEK PVRIYN
//
