ID A0A1S3ZA08_TOBAC Unreviewed; 518 AA.
AC A0A1S3ZA08;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN Name=LOC107784649 {ECO:0000313|RefSeq:XP_016461290.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016461290.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016461290.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR RefSeq; XP_016461290.1; XM_016605804.1.
DR AlphaFoldDB; A0A1S3ZA08; -.
DR STRING; 4097.A0A1S3ZA08; -.
DR PaxDb; 4097-A0A1S3ZA08; -.
DR GeneID; 107784649; -.
DR KEGG; nta:107784649; -.
DR OMA; SKVNWMM; -.
DR OrthoDB; 444471at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006679; P:glucosylceramide biosynthetic process; IBA:GO_Central.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 518 AA; 58331 MW; 4C26E9CAC836F02A CRC64;
MLPLDSFDKF LFSASRALCS PLAVFIQIQG CFICLVLALG WALAAYVRGR EIRRMKDSMR
CGNSFAFLTK DINDLEHSNQ VNLPPVSVVM PLKGFGEHNL HNWRSQITSL YGGPLEFLFV
VESTADPAYH AVKRLLADFK DVDAKIIVAG LSTTCSQKIH NQLVGVEKMH KDTKYVLFLD
DDVRLHPGSI GALTTEMEKN PEIFIQTGYP LDLPSGTLGS YCIYEYHMPC SMGFATGGKT
FFLWGGCMMM HADDFRTDRH GVVSALRDGG YSDDMTLAAI AEEHKRLITS PPVAVFPHPL
ASDLTFPRYW NYLRKQTFVL ESYTTKVNWI MNRALFTTHC YLSWGFVTPY VMAGIHVAAA
LRFYFKGYSP DDTVLKCNGL LLAGCLAICT LIELLSMWNL TRIEVHLCNM LSPEAPQLSL
ASYNWCLVFI AMLVDNFLYP LSAMRSHFSQ SINWSGIRYH LKDGKIYKID RHKHLVPKIT
DLAGKDLLGK NGSTPKVAII SSLSRTLAQW RQPKKYDV
//
